ANIMAL FACIL: ALLERGIC AIRWAY

描述（由申请人提供）：拟议的建设项目将使范德比尔特大学北医疗中心（MCN）扩建动物设施的外壳空间成为可能。目前，大学正在MCN的屋顶上建造一个三层的鼠标设施（在本申请中称为MCNII）；六层（员工）和八层（老鼠）；生物安全3级防护套件；啮齿动物定量组；清洗笼]将于2002年春季完成。不幸的是，有限的大学资源要求七楼（容纳11,000个笼子）是壳空间。然而，这个空间对于容纳正在招聘的现有教师的资助的、未决的和计划中的同行评议的研究项目是绝对必要的。其中一些项目是多学科的，涉及创建和筛选小鼠模型。大学积极管理群体规模，为研究人员提供小鼠胚胎冷冻保存和繁殖以及群体监测的核心功能。尽管做出了这些努力，但仍迫切需要鼠标的握持空间。这个应用程序概述了范德比尔特大学的整体战略动物空间规划。随着小鼠研究项目的增加，需要当前对小鼠设施的投资和建设，以及对科学研究的看法。资金被要求建造原本是外壳空间的地方，以增加40%的老鼠住房容量。

DESCRIPTION (provided by applicant): The proposed construction project will make possible the build out of shell space for an expanded animal facility in Medical Center North (MCN) at Vanderbilt University. Currently, the University is building a three-floor mouse facility on the rooftop of MCN (referred to as MCNII throughout this application); floors six (staff) and eight [mice; Biosafety Level 3 containment suite; rodent quantitative suites; cage washing] will be completed in spring 2002. Unfortunately, limited University resources have required that floor seven (11,000 cage holding capacity) be shell space. Yet this space is absolutely essential to accommodate funded, pending and planned peer-reviewed research programs of existing faculty under recruitment. Several of these programs are multidisciplinary and involve creating and screening mouse models. The University aggressively manages colony size by providing investigators with core functions for mouse embryo cryo-preservation and breeding and colony monitoring. Despite these efforts, there is desperate need of mouse holding space. This application outlines the overall strategic animal space planning at Vanderbilt University. The growth in mouse research projects required the current investment in and building of additional mouse facilities, and a perspective on the scientific research. Funds are requested to build-out what otherwise would be shell space to increase mouse housing capacity by 40 percent.