ANIMAL FACIL: CANCER

描述(由申请人提供)：拟议的建设项目将使范德比尔特大学北部医学中心(MCN)的扩建动物设施的外壳空间成为可能。目前，该大学正在MCN(在本申请中称为MCNII)的屋顶上建造一个三层楼的老鼠设施；六楼(工作人员)和八楼[老鼠；生物安全3级隔离套间；啮齿动物数量套间；笼子清洗]将于2002年春季完工。不幸的是，有限的大学资源需要七楼(可容纳11,000个笼子)作为外壳空间。然而，这个空间对于容纳正在招聘的现有教员的资助、待定和计划的同行审查研究项目来说是绝对必要的。其中有几个项目是多学科的，涉及到创建和筛选老鼠模型。该大学通过为研究人员提供小鼠胚胎冷冻保存和繁殖以及群体监测的核心职能，积极管理群体大小。尽管做出了这些努力，但仍迫切需要鼠标握持空间。这份申请概述了范德比尔特大学动物空间的总体战略规划。老鼠研究项目的增长需要目前对更多老鼠设施的投资和建设，以及对科学研究的看法。需要资金来建造否则将是外壳空间的地方，以将鼠标的容纳量增加40%。

DESCRIPTION (provided by applicant): The proposed construction project will make possible the build out of shell space for an expanded animal facility in Medical Center North (MCN) at Vanderbilt University. Currently, the University is building a three-floor mouse facility on the rooftop of MCN (referred to as MCNII throughout this application); floors six (staff) and eight [mice; Biosafety Level 3 containment suite; rodent quantitative suites; cage washing] will be completed in spring 2002. Unfortunately, limited University resources have required that floor seven (11,000 cage holding capacity) be shell space. Yet this space is absolutely essential to accommodate funded, pending and planned peer-reviewed research programs of existing faculty under recruitment. Several of these programs are multidisciplinary and involve creating and screening mouse models. The University aggressively manages colony size by providing investigators with core functions for mouse embryo cryo-preservation and breeding and colony monitoring. Despite these efforts, there is desperate need of mouse holding space. This application outlines the overall strategic animal space planning at Vanderbilt University. The growth in mouse research projects required the current investment in and building of additional mouse facilities, and a perspective on the scientific research. Funds are requested to build-out what otherwise would be shell space to increase mouse housing capacity by 40 percent.