Physipatogenesis of malaria anemia in humans & monkeys

描述（改编自应用程序）： 本建议中所述培训的目的是最佳利用 有没有可能对 自然条件下的人类和实验性疟疾引起的贫血 感染猴子Aotus猴代表了一个非常有价值的研究模型 贫血的生理发病机制，特别是当它与 预防针我们小组和其他人以前进行的研究表明， 在临床前阶段， 疟疾疫苗试验我们的TMRC计划将包括人类的研究 自然暴露于恶性疟原虫和间日疟原虫传播的社区。 我们计划解决缺乏贫血患病率信息的问题 在这些社区，与其生产相关的因素，如 与营养和遗传特征有关（即血红蛋白病）。 我们建议举办的培训活动， 哥伦比亚和拉丁美洲的研究生和博士后学生短期 为基础科学家、临床医生和 卫生工作者。将向来自疟疾的临床医生提供临床轮换 为了提高他们的诊断和管理技能， 严重的疟疾，特别是严重的贫血。此外，我们计划建立 一个贫血的网站。其中最具成本效益的活动之一， 培训计划，可能是计划与 卫生部和泛美卫生组织。这些研讨会将接近最 由击退疟疾计划选择的相关问题。 培训地点和设施包括TMRC计划的培训地点和设施， 包括：a）一个具有临床和研究实验室的现场， 一家二级医院和一家二级医院。B）一套实验室， 分子生物学、免疫学、蛋白质化学和体外寄生虫 cultures.（c）一个有Aotus猴和Saimiri猴的灵长类中心。（d）两个 位于卡利的三级医院。所有这些设施和活动 将由行政和视察委员会协调， TMRC的科学家核心。 教学人员包括免疫学家，血液学家，流行病学家， 统计学家、传染病专家、儿科医生和 病理学家我们将联合收割机的专业知识，著名的科学家， 哥伦比亚、巴西、委内瑞拉和美国。一些合作的科学家 来自哥伦比亚和拉丁美洲其他疟疾流行国家的 美国，已经联系并将提供实习生候选人。见习 候选人将在竞争的基础上挑选，并对 在培训期间，在每年结束时提出成果 咨询小组会议。这些活动将受益于长期的 国际培训的传统，在卫生学院的发展， 卡利的瓦莱大学。

DESCRIPTION (adapted from the application): The purpose of the training described in this proposal is to make optimal use of the possibility to conduct comparative studies between malaria developed by humans in natural conditions and anemia induced by experimental malaria infection in monkeys. Aotus monkeys represent a very valuable model to study the physio-pathogenesis of anemia, particularly when it is associated to vaccination. Previous studies conducted by our group and by others, indicate that severe anemia develops in Aotus monkeys during the course of pre-clinical malaria vaccine trials. Our TMRC program will include the study of human communities naturally exposed to both P. falciparum and P. vivax transmission. We plan to approach a lack of information concerning the prevalence of anemia in those communities, the factors associated to its production such as those related to nutrition and to genetic features (i.e. Hemoglobinopathies). We propose to carry out training activities that cover from long term training of Colombian and Latin American graduate and post-doc students to short term seminars, workshops and summer courses for basic - scientists, clinicians and health workers. Clinical rotations will be offered to clinicians from malaria endemic areas in order to improve their skills in diagnosis and management of severe malaria, particularly severe anemia. Furthermore, we plan to establish a Web Site for Anemia. One of the most cost-effective activities in this training program, may be the workshops planned to be organized jointly with the Ministries of Health and PAHO. These workshops will approach the most relevant issues selected by the RollBack Malaria program. The training sites and facilities include those of the TMRC program that comprises: a) A field-site with clinical and research laboratories, insectaries and a second level hospital. b) A set of laboratories for molecular biology, immunology, protein chemistry, and parasite in vitro cultures. c) A primate center with both Aotus and Saimiri monkeys. d) Two third-level hospitals located in Cali. All these facilities and the activities developed in them will be coordinated by the Administrative and Visiting Scientist Cores of the TMRC. The teaching staff involves immunologists, hematologists, epidemiologist, statisticians, infectious diseases - specialists, pediatricians and pathologists. We will combine expertise of well-known scientists from Colombia, Brazil, Venezuela and the USA. A number of collaborating scientists and institutions from Colombia and other malaria endemic countries of Latin America, have been contacted and will provide trainee candidates. Trainee candidates will be selected on a competitive basis and an evaluation of outcome is proposed at the end of each yearly period, during the Training Advisory Group (TAG) meeting. These activities will profit from a long tradition of international training developed at the School of Health of Universidad del Valle, in Cali.