RENOV OF CHEMISTRY BLDG: PROTEIN STRUCT, SENSOR TECH, ANTHRAX, ION TRANSPORT

描述(由申请人提供)：翻新化学大楼以增加现代研究设施的数量对阿肯色大学生物医学研究的未来至关重要。超过13,000平方米。英国《金融时报》由这里申请的资金翻新的生物医学研究空间将用于教职员工研究小组以及共享仪器实验室。长期目标是扩大和改善生物医学研究的可用空间，并允许此类研究继续增长。具体目标：1)本申请中讨论的建筑整体以及具体的生物医学研究空间将被提升到符合所有现行法规和法规的标准。所有的机械和电气系统将被完全更换，大部分内部空间将被重新安排，以最好地满足研究需求；2)实验室将进行改造，以容纳Francis Millett、Bill Durham、Matt McIntosh、Kenneth Turnbull和Chin Yu博士的研究小组以及一名新的教员；3)将为蛋白质X射线结晶学实验室、蛋白质核磁共振实验室、蛋白质结构解决方案和可视化计算机实验室以及质谱学实验室提供共用的仪器空间；以及4)这种扩大和改进的空间将用于扩大现有的核酸化学、药物合成和电子传输小组。它将用于建立一个新的蛋白质核磁共振小组和一个组合药物发现研究小组。共享的仪器实验室将用于研究和阐明支配蛋白质结构和功能的基本原理。腾出的空间将用于扩大其他群体的生物医学研究努力。

DESCRIPTION (provided by applicant): Renovation of the Chemistry Building to increase the amount of modern research facilities is critical for the future of biomedical research at the University of Arkansas. The over 13,000 sq. ft. of biomedical research space renovated by the funding requested here will be used for faculty research groups as well as for shared instrumentation laboratories. The long-term goal is to expand and improve the space available for biomedical research and allow continued growth of such research. Specific Aims: 1) The building overall as well as the specific biomedical research spaces discussed in this application will be brought up to a standard meeting all current codes and regulations. All mechanical and electrical systems will be completely replaced and most interior spaces rearranged to best meet research needs; 2) Laboratories will be renovated to house the research groups of Drs. Francis Millett, Bill Durham, Matt McIntosh, Kenneth Turnbull, and Chin Yu as well as one new faculty member to be hired; 3) Shared instrumentation space will be provided for Protein X-ray Crystallography Laboratory, Protein Nuclear Magnetic Resonance (NMR) Laboratories, Protein Structure Solution and Visualization Computer Laboratory, and Mass Spectrometry Laboratories; and 4) This expanded and improved space will be used to expand existing nucleic acid chemistry, drug synthesis, and electron transport groups. It will be used to establish a new protein NMR group and a combinatorial drug discovery research group. The shared instrumentation laboratories will be used for the study and elucidation of the fundamental principles that govern the structure and function of proteins. Vacated space will be used to expand biomedical research efforts of other groups.