NEUROSCI FACIL: IMMUNE RESPONSE, DNA & PROTEIN IMMUNOGENS FOR SIV/HIV VACCINES

关于艾滋病：描述（由申请人提供）：本申请要求资金建造一个带壳的地板（16,000平方米）。（英尺）这将完成一座三层楼的建筑，旨在扩大YRPRC的神经科学研究。伍德拉夫健康科学中心和YRPRC进行的战略分析导致了一项决定，即最大限度地利用YRPRC校园的有限空间，并从欧盟获得大量资金承诺，以显着扩大先前计划的神经科学大楼。这一决定是认识到在YRPRC资助的研究的急剧增长（在过去两年中增加了50%以上）和满足神经科学和传染病研究（在YRPRC研究的两个关键领域）的国家健康需求的重要性。因此，现在可从欧盟获得资金（1 100万美元），并在2000年9月获得了先前的C 06合同（1C 06 RR 15461 -01，200万美元），该合同将允许建造一座总面积为48 000平方米的三层建筑。英尺现有资金将允许建造和扩建两个完整的楼层，但只能炮击第三层。本申请要求提供必要的资金来扩建新大楼的第三层，以便为在行为神经科学中进行灵长类动物研究的研究人员提供动物试验区、实验室空间和研究支持空间。额外的空间将允许在一个中心位置巩固神经科学研究人员，并为新招募的教师提供急需的新实验室测试区域，包括YRPRC的新主任（Stuart Zola博士），为现有的教师，其计划正在增长，以及教师正在招募加入YRPRC和欧盟的神经科学社区。此外，一些教师将从YRPRC微生物和免疫学系的临时占用空间搬迁到新大楼的三楼，腾出的空间用于扩大疫苗研究项目。额外的空间将大大提高YRPRC研究和培训的质量和范围，大大增加与该地区其他研究人员的合作数量，并大大提高该中心满足国家卫生需求的能力。

Regarding AIDS: DESCRIPTION (provided by applicant): This application requests funds to build-out a shelled floor (16,000 sq. ft.) that would complete construction of a three-story building designed to expand neuroscience research at the YRPRC. A strategic analysis conducted by Woodruff Health Sciences Center and the YRPRC has led to a decision to maximize use of the limited space available at the YRPRC campus, and to a substantial commitment of funds from EU to significantly enlarge the previously planned neuroscience building. This decision was taken in recognition of the dramatic growth of funded research at the YRPRC (an increase of more than 50 percent during the last two years) and the importance of meeting national health needs of neuroscience and infectious disease research (two key areas of research at the YRPRC). Accordingly, funds are now available from EU ($11 million) and a previous C06 award funded in September 2000 (1C06RR15461-01, $2 million) that will permit construction of a three-story structure totaling 48,000 sq. ft. Available funds will allow the construction and build-out of two full floors, but only the shelling of a third floor. The present application requests funds necessary to build-out the third floor of the new building in order to provide animal test areas, laboratory space, and research support space for investigators conducting primate research in behavioral neuroscience. The additional space will allow to consolidate neuroscience investigators in a central location and to provide vitally needed new laboratory-testing areas for newly recruited faculty, including the new Director of the YRPRC (Dr. Stuart Zola), for existing faculty whose programs are growing, as well as faculty being recruited to join the neuroscience community at YRPRC and EU. In addition, some faculty will be relocated to the third floor of the new building from temporary occupancy of space in the YRPRC, Division of Microbiology and Immunology, with the vacated space used to expand program in vaccine research. The additional space will significantly enhance both the quality and scope of research and training at the YRPRC, substantially increase the number of collaborations with other investigators in the region, and dramatically improve the Center's ability to meet national health needs.