ROLE OF SRC 1 IN SEXUAL DIFFERENTIATION OF RAT BRAIN

描述（申请人摘要）：对细胞过程的理解 在围产期影响大脑的性别分化 是重要的，因为它们对正常行为有持久的影响， 动物的生理学。围产期性激素暴露 经期既可以使大脑男性化，也可以使大脑女性化。由于性腺激素影响 通过与位于脑内的细胞内类固醇受体结合， 大脑，重要的是要了解类固醇激素如何相互作用， 类固醇受体影响基因组活动， 发展最近的研究报道，类固醇受体与 其他基因转录所必需的蛋白质。一种这样的蛋白质， 称为类固醇受体辅激活因子-1（SRC-1），已知对于 然而，不知道SRC-1是否 类固醇在大脑中起作用所必需的。在目前的系列 在实验中，我们将确定SRC-1的表达是否是性二态性的， 大脑发育过程中，并确定SRC-1蛋白是否需要 类固醇在大脑中的作用。

DESCRIPTION (applicant's abstract): An understanding of the cellular processes that influence sexual differentiation of the brain during the perinatal period is important as they have enduring consequences on the normal behavior and physiology of an animal. Exposure to gonadal hormones during the perinatal period can either masculinize or feminize the brain. As gonadal hormones affect brain development by binding to intracellular steroid receptors located within the brain, it is important to understand how steroid hormones interact with steroid receptors to influence genomic activity and ultimately brain development. Recent studies have reported that steroid receptors interact with other proteins that are necessary for gene transcription. One such protein, called steroid receptor coactivator-1 (SRC-1), is known to be obligatory for steroid action in in vitro preparations however, it is not known if SRC-1 is required for steroid action within the brain. In the present series of experiments, we will determine if SRC-1 expression is sexually dimorphic within the brain during development and determine if SRC-1 protein is required for steroid action within the brain.