HEALTH BURDEN OF CO INFECTING DEER ASSOCIATED ZOONOTIC CNS DISEASE

在美国东部鹿多的地区，一系列螺旋体、原生动物、病毒和立克次体病原体同时感染居民。鹿的数量和依赖于这种宿主的媒介节肢动物的数量最近都有所增加。这些与鹿有关的病原体中有几种会导致神经系统疾病。这项研究的目的是(1)确定美国东北部居民中与鹿相关的病原体引起脑膜炎和脑炎的频率以及这些病原体联合出现的频率；(2)估计这些与鹿相关的病原体对人类健康造成的负担，并确定糖果是否协同致病作用。我们将观察由这些病原体引起的脑膜炎或脑炎的结果，以及合并感染的人是否比只有一种病原体时经历更严重的急性疾病或更大的神经后遗症。

An array of spirochetal, protozoan, viral and rickettsial pathogens concurrently infect residents of sites in eastern US in which deer are abundant. The abundance of deer and that of the vector arthropods that depend on this host recently have increased. Several of these deer-associated pathogens cause neurologic disease. The objectives of this study are to (1) determine how frequency meningitis and encephalitis are caused by deer-associated pathogens in residents of the northeastern US and how frequently these pathogens occur in combination; (2) Estimate the burden on human health imposed by these deer-associated pathogen and determine whether confection synergizes pathogenesis. We will look at the outcome following meningitis or encephalitis caused by these pathogens, and whether coinfected people experience a greater severity of acute illness or greater neurologic sequelae than if only one such pathogen were present.