CYTOSKELETAL ORGANIZATION AND MALIGNANT TRANSFORMATION

描述（申请人描述）：该项目旨在培养博士后和博士后水平的研究人员，他们将能够将细胞信号转导的基本机制（包括细胞骨架和膜现象）的知识应用于恶性转化的细胞生物学问题。在细胞骨架和膜组织的更广泛的方面，以及在癌症生物学方面，已经开发了正式的培训课程。这些包括：(1)细胞设计原理：一门高级细胞生物学课程，强调细胞骨架和膜研究的发展。(2)癌症：基础科学方法：讲座、报告和相关研讨会，强调肿瘤发生机制、病因学和特定癌症的治疗机制。博士前研究员必须参加这些课程。鼓励博士后旁听，以补充他们的背景。“细胞骨架和恶性转化”系列研讨会、期刊俱乐部、信号转导研究报告和静修是该计划非正式培训的一部分。导师包括一群癌症研究人员，他们与具有不同技术和专业知识的基础细胞生物学家进行互动。导师实验室和学员专注于从外部刺激到分子和结构反应的细胞信号转导途径，包括细胞骨架和膜组装，细胞质运动分子的激活，蛋白质靶向等基本问题。鼓励学员将这些方法应用于癌症相关问题，如转移、多药耐药和细胞生长控制。结构、生化、药理学、免疫学、分子生物学和遗传学方法由导师实验室代表。在这个项目的研究员能够体验到观点的多样性，针对在细胞和癌症生物学之间的界面的共同问题。指导委员会与计划主任一起作为执行委员会，负责选择研究员、重新任命他们以及评估他们的进展。

DESCRIPTION (Applicant's Description): This program seeks to train investigators at the pre and postdoctoral levels, who will be capable of applying knowledge of basic mechanisms of cellular signal transduction involving cytoskeletal and membrane phenomena to questions of the cell biology of malignant transformation. Formal training courses in both broader aspects of cytoskeletal and membrane organization, and in the biology of cancer, have been developed. These include: (1) Cellular Design Principles: an advanced cell biology course emphasizing developments in cytoskeletal and membrane research. (2) Cancer: A Basic Science Approach: lectures, presentations and related seminars, emphasizing mechanisms of oncogenesis, etiology and mechanisms of treatment of specific cancers. Predoctoral Fellows are required to take these courses. Postdoctoral Fellows are encouraged to audit to supplement their background. A "Cytoskeletal and Malignant Transformation" seminar series, journal clubs, signal transduction research presentations, and retreats form part of the informal training component of this program. Preceptors include a cadre of cancer investigators who interact with basic cell biologists with different technical and programmatic expertise. Preceptor laboratories and trainees concentrate on the cellular signal transduction pathway from external stimulus to molecular and structural response, including basic problems such as cytoskeletal and membrane assembly, activation of motor molecules of the cytoplasm, and protein targeting. Trainees are encouraged to apply such approaches to cancer-related problems such as metastasis, multi-drug resistance and cell growth control. Structural, biochemical, pharmacological, immunological, molecular biological, and genetic approaches are represented by the preceptor laboratories. Fellows in this program are able to experience the diversity of points of view, directed toward common problems at the interface between cell and cancer biology. A steering committee, together with the program director, acts as an executive board for selection of fellows, their reappointments and evaluation of their progress.