NC Colorectal Cancer Care Outcomes Research Study

描述(由申请人提供)： 患有结直肠癌的负担是沉重的。尽管在那里 在了解结直肠癌的生物学方面取得了巨大的进展 癌症治疗方面的重要进展，目前尚缺乏相关知识 关于特定过程措施对健康和行为的影响 结果。拟议研究的长期目标是建立一个 检查护理过程与临床和临床的关系的系统 病人护理结果。本研究的具体目的是：1)评估 根据患者、健康状况获得癌症护理服务的决定因素 护理提供系统和医生的特点。2)描述变体 在脆弱人群中的癌症实践模式。3)纵向至 评估一系列临床和以患者为中心的健康结果。4)至 确定影响患者、提供者和医疗系统的因素 传播有效的干预措施。5)评估以下方面的贡献 生活方式因素对预后和结局的影响。6)检查合并症， 诊断性检查、外科治疗和分期检查的细节 种族差异。这项研究将招募1000名以人口为基础的队列 中部22个县区新诊断的结直肠癌患者 以及北卡罗来纳州东部。为了评估种族差异，这项研究将 包括同等数量的黑人和白人。病例将通过使用 北卡罗来纳州中央癌症登记处的快速查明机制 使用正在进行的以人群为基础的病例对照研究的方法。案件将会 接受电话采访和邮寄调查。医疗审查中心的工作人员 北卡罗来纳州，一个非营利性的质量改进组织，将抽象 医院记录和医生办公室病历。专项研究项目将 1)评价功能性健康素养对治疗和治疗的影响 结果；2)收集血液样本和肿瘤块以创建 用于未来分析的生物储存库。

DESCRIPTION (provided by applicant): The burden of suffering from colorectal cancer is substantial. Although there has been tremendous progress in understanding the biology of colorectal cancer, and important advances in treatment, there is a lack of knowledge about the effect of specific process measures on health and behavioral outcomes. The long-term objective of the proposed study is to establish a system to examine the relationship of processes of care to clinical and patient care outcomes. The specific aims of this research are: 1) To assess determinants of access to cancer care services according to patient, health care delivery system and physician characteristics. 2) To describe variations in cancer practice patterns in vulnerable populations. 3) To longitudinally assess a range of clinical and patient-oriented health outcomes. 4) To identify patient, provider, and health system factors influencing the dissemination of effective interventions. 5) To assess the contribution of lifestyle factors on prognosis and outcomes. 6) To examine comorbid illness, diagnostic workup, surgical management and details of staging to investigate racial disparity. The study will enroll a population-based cohort of 1000 newly diagnosed colorectal cancer patients from a 22-county area in central and eastern North Carolina. To evaluate racial disparities, the study will include equal numbers of blacks and whites. Cases will be identified using the rapid ascertainment mechanisms of the North Carolina Central Cancer Registry using methods from an ongoing population-based case-control study. Cases will be interviewed by telephone and mailed surveys. Staff from Medical Review of North Carolina, a non-profit quality improvement organization, will abstract hospital records and physician office charts. Special research projects will 1) evaluate the effect of functional health literacy on treatment and outcomes; 2) collect blood specimens and tumor blocks to create a biorepository for future analyses.