Regioselective reactions of arynes and heteroarynes

芳炔和杂芳炔，如吡啶炔是反应性化学中间体。控制这些分子的反应位置仍然具有挑战性。我们之前已经开发了一种快速获取异芳炔相关前体的方法。我们现在将开发吡啶和芳烃的新反应：区域选择性亲核功能化，C-H功能化和新试剂的双功能化。通过这一研究项目获得的基本知识将有助于改进合成方法，使整个精细化学工业受益。这项研究是EPSRC-Dial-a-Molecule大挑战中心目标的重要一步。

Arynes and heteroarynes such as pyridynes are reactive chemical intermediates. Controlling the site of reactions of these molecules remains challenging. We have previously developed a rapid access to relevant precursors of heteroarynes. We will now develop new reactions of pyridynes and arynes: regioselective nucleophilic funtionalisation, C-H functionalisation, and bis-functionalisation with novel reagents. The fundamental knowledge gained through this research project should enable the development of improved synthetic methodologies that will benefit the fine chemical industry at large. The proposed research constitutes an important step towards the central goals of the EPSRC-Dial-a-Molecule grand challenge.