Dynamics and mechanisms of neutrophil migration during tissue inflammation

中性粒细胞是炎症和感染的中心介质。目前尚不清楚中性粒细胞如何在炎症组织中穿行，以及它们如何检测受损细胞和/或病原体。本提案将使用尖端的多光子显微镜来实时剖析活体动物中性粒细胞行为的动力学和机制。这些实验将为炎性疾病的发展提供新的认识。

Neutrophil granulocytes are central mediators of inflammatory conditions and infections. It is currently unclear how neutrophils navigate through inflamed tissues and how they detect damaged cells and/or pathogens. This proposal will use cutting-edge multi-photon microscopy to dissect the dynamics and mechanisms of neutrophil behaviour in real time in living animals. These experiments will provide a new understanding of the development of inflammatory diseases.