Understanding the mechanistic uptake and exploring the translation of novel amino acid based ion pair complexes

本项目旨在研究在不同浓度的带相反电荷的氨基酸存在下，模型渗透性差的药物渗透性增强的细胞机制。该项目涉及各种技术的应用，包括药物渗透性评估，物理表征，如溶解度评估，差示量热分析以及微生物测定，如速率杀灭研究和微生物中的药物摄取测定。该项目将提供涉及物理化学、微生物学和药物配制的跨学科科学方面的专门知识。

The Project aims to study the cellular mechanism of enhancement of permeability of model poorly permeable drugs in the presence of different concentration of oppositely charged amino acids. The project involves the application of various techniques including drug permeability assessment, physical characterisation such as solubility assessment, differential calorimetric analysis as well as microbial assays such as rate kill studies and drug uptake assays in microbes. The project will provide expertise in interdisciplinary sciences involving physical chemistry, microbiology and drug formulation.