Total Synthesis of an Anti-HIV Natural Product

含有大量小分子的文库的生产，与高通量筛选方法相结合，在寻找新药方面发现了很大的用途。然而，天然产物作为生物活性结构的来源，对制药和农化工业仍然很重要。此外，它们还可以协助确定新的目标，以供进一步调查。合成有机化学在通过天然产物及其类似物的合成和修饰来帮助这一追求方面具有独特的地位。在这项提议中，我们的目标是合成一种最近分离的天然产品，它已被证明对目前使用的治疗方法耐药的菌株具有抗HIV活性。关键的分离将使用一个小的有机分子作为催化剂，使复杂的分子结构能够快速和有效地构建。作为牛津生物和医学合成博士培训中心的一部分，该项目拥有众多的制药和农化工业合作伙伴。这一开放获取系统允许自由交流思想，以协助该项目。

The production of libraries containing vast numbers of small molecules, in combination with high-throughput screening methods, has found much use in the search for new drugs. However, natural products remain important to the pharmaceutical and agrochemical industries as a source of biologically-active structures. In addition, they can assist in the identification of novel targets for further investigation. Synthetic organic chemistry is in a unique position to assist this pursuit through the synthesis and modification of natural products and their analogues.In this proposal, we aim to synthesise a recently isolated natural product that has been shown to possess anti-HIV activity against strains resistant to currently used treatments. The key disconnection would use a small organic molecule as a catalyst to enable rapid and efficient construction of the complex molecular structure.As part of the Synthesis for Biology and Medicine Doctoral Training Centre in Oxford, this project has numerous pharmaceutical and agrochemical industrial partners. This open-access system enables free exchange of ideas to assist the project.