CANADIAN CONTRIBUTION TO NCI INTERGROUP CANCER TRIALS

此应用程序的目标是增强改进 通过合作临床试验治疗癌症患者。 随机临床试验提供了关于 不同形式的治疗效果;因此，国家 癌症研究所（NCI）资助了临床试验小组， 开展和开展这些研究。 现在很清楚，虽然 在许多情况下，这些团体往往可以独立进行重要的审判， 他们之间需要合作来回答关键问题 尽快 因此，制定和开展 “组间”试验已经实施， 已完成 加拿大国家癌症研究所，一个由捐款资助的机构， 加拿大癌症协会，支持临床试验组（NCIC CTG），其功能和结构与美国集团相似。 像我们这样 NCIC CTG已经进行了许多自己的研究， 为制定现行标准做出了重要贡献。 在乎 NCIC CTG还积极参与组间试验， 作为一个“领导者”和一个“领导者”。 本申请的直接目的是寻求支持， 继续并加强国家犯罪信息中心CTG参与美国的 研究的具体目标如下：1。贡献病人 注册，数据管理资源和高质量的数据， NCI赞助的组间试验; 2.提供科学投入， NCI组间试验的开发设计和实施; 3.到 为一些NCI团体间提供领导和协调资源 审判 如果没有本申请中寻求的资金，NCIC CTG可以在 最好是对重要的研究工作做出有限的贡献， 以组间试验为代表。 有了它，小组可以帮助双方 定义要解决的问题并确保它们得到解答 快速而正确地。

The goal of this application is to enhance the process of improving the treatment of cancer patients through cooperative clinical trials. Randomized clinical trials provide the best evidence concerning the effectiveness of different forms of therapy; consequently the National Cancer Institute (NCI) has funded clinical trials groups dedicated to developing and conducting these studies. It is now clear that, although these groups can often undertake important trials independently, in many cases cooperation among them is needed to answer key questions expeditiously. Thus, formal mechanisms for developing and conducting "intergroup" trials have been implemented and a number of such studies have been completed. The National Cancer Institute of Canada, an agency funded by donations to the Canadian Cancer Society, supports a clinical trials group (NCIC CTG) which has functions and a structure similar to US groups. Like US groups, the NCIC CTG has conducted numerous studies of its own and has made important contributions to the development of current standards of care. The NCIC CTG has also been active in intergroup trials, both as a participating and as a "lead" group. The immediate purpose of this application is to seek support for continued and enhanced participation of the NCIC CTG in US intergroup studies with the following specific aims: 1. To contribute patient enrolment, data management resources, and high quality data to intergroup trials sponsored by NCI; 2. To provide scientific input into the development design and conduct of NCI intergroup trials; and 3. To provide leadership and coordination resources for some NCI intergroup trials. Without the funding sought in this application, the NCIC CTG can, at best, make a limited contribution to the important research effort represented by intergroup trials. With it, the Group can help both in defining the questions to be addressed and in ensuring they are answered quickly and correctly.