Structural domains of beta-tubulin and their role in microtubule dynamics and transport

本研究旨在对细胞骨架蛋白β -微管蛋白的结构域如何参与细胞分裂和囊泡运输过程中的微管结构有一个基本的了解。使用基因编辑技术并将其与细胞生物学方法和高分辨率细胞成像相结合，将能够详细分析β -微管蛋白结构域在这些重要细胞过程中的作用。其成果将包括细胞生物学的基本新知识，并导致可用于了解疾病的独特生物学模型的发展。

This study aims to obtain a fundamental understanding of how the structural domains of the cytoskeletal protein beta-tubulin are involved in microtubule structures during cell division and vesicular transport. Using gene-editing technology and coupling this with cell biological approaches and high-resolution cell imaging will enable detailed analysis of the role of beta-tubulin domains in these important cellular processes. The outcomes will include fundamental new knowledge in cell biology and lead to the development of unique biological models that can be used to understand disease.