PROSPECTIVE STUDY OF BODY DYSMORPHIC DISORDER

本提案的目标是前瞻性地调查 身体畸形性障碍（BDD）及其妄想性障碍变体的过程， 200名3至4岁的成人和青少年。身体畸形恐惧症 经常是对想象中的或轻微的外表缺陷的妄想性关注， 是一种令人痛苦的，有害的，代价高昂的疾病，比 一般承认。这种调查很重要，因为BDD似乎 通常是慢性的，并在一生中造成相当大的发病率。是 与社会和学术/职业障碍的高发生率相关， 居家、精神病住院、自杀意念和自杀 尝试.只有最少的数据是关于纵向路线， BDD的结果。因此，对症状的临床过程知之甚少 严重程度、社会心理功能和生活质量。 该提案的总体目标是进行第一次前瞻性研究， BDD及其妄想型的病程和转归的纵向研究 （妄想症，躯体型）。具体目标如下：1） BDD的地图模式; 2）识别预测因子/中介变量 与缓解和复发相关; 3）描述手术，皮肤病学， 接受其他医疗和精神治疗，并检查协会 治疗和疗程之间的关系;以及4）描述心理社会功能， 生活质量随时间的变化，并评估其与BDD症状的关系 严重性和妄想性受试者将在每年的 使用获得详细信息的可靠和有效的工具进行间隔 症状状态和严重程度，诊断状态，治疗利用， 心理社会功能、生活质量和其他领域。拟定研究 这将是第一个关于BDD的前瞻性研究。Findings from the 这项研究将为临床和理论上的重要问题提供新的线索 关于一个严重的和相对常见的，但未被认识和研究， disorder.

The goal of this proposal is to investigate prospectively the course of body dysmorphic disorder (BDD) and its delusional disorder variant in 200 adults and adolescents over 3 to 4 years. Body dysmorphic disorder, an often-delusional preoccupation with an imagined or slight defect in appearance, is a distressing, impairing, and costly disorder that is more common than is generally recognized. Such investigation is important because BDD appears to often be chronic and to cause considerable morbidity over the life span. It is associated with high rates of social and academic/occupational impairment, being housebound, psychiatric hospitalization, suicidal ideation, and suicide attempts. Only minimal data are available on the longitudinal course and outcome of BDD. Thus, little is known about the clinical course of symptom severity, psychosocial functioning, and quality of life. This proposal's broad objective is to conduct the first prospective longitudinal study of the course and outcome of BDD and its delusional variant (delusional disorder, somatic type). The specific aims are the following: 1) map patterns of course for BDD; 2) identify predictors/mediating variables associated with remission and relapse; 3) describe surgical, dermatologic, other medical, and psychiatric treatment received, and examine the association between treatment and course; and 4) describe psychosocial functioning and quality of life over time, and assess their relationship with BDD symptom severity and delusionality. Subjects will be carefully evaluated at annual intervals with reliable and valid instruments that obtain detailed information on symptom status and severity, diagnostic status, treatment utilization, psychosocial functioning, quality of life and other domains. The proposed study will be the first prospective study of the course of BDD. Findings from the study will shed new light on clinically and theoretically important questions about a severe and relatively common, yet underrecognized and understudied, disorder.