MODULATION OF NEURONAL RESPONSES IN SOMATOSENSORY CORTEX

描述：(改编自《调查者摘要》) 在触觉物体识别中，我们注意并记住选定的特征 在集成导致识别的信息的同时顺序触摸。 为了理解这一复杂的过程，我们建议使用全脑功能 人类磁共振成像(FMRI)和单神经元记录研究 在猴子身上，他们接受了触觉记忆任务的训练，以研究 触觉潜在的感觉和认知过程的功能解剖 注意力和记忆力。 我们提出了五个相互关联的功能磁共振实验，它们将确定：(A) 初级躯体感觉皮质专用于选择性激活 每个指尖上的受体(实验1-2)，(B)皮质区域网络 参与了触觉注意的认知过程(实验3-4)，以及(C) 与触觉记忆相关的网络(实验5)。前两个实验测试 注意与记录的动态调节有关的假设 体视图。后两个实验主要关注的是 注意振动的刺激属性的功能解剖学 频率、表面粗糙度和触觉刺激持续时间。五号 实验考察了工作记忆任务中的功能解剖 用于振动频率。Exp 3-5中发现的重叠病灶将提示 可能用于触觉对象识别的网络，因为这些区域将 在记忆和注意力过程中是常见的。 两项神经生理学研究(实验6a、6b)将记录 额叶和躯体感觉皮质的感觉和工作记忆，可能 在功能核磁共振研究中被确认。因此，这些对单个神经元的观察 将在记忆触觉的延迟间隔期间显示不同的活动 刺激，因此，突出了可能的时间动力学潜在的 人体研究中的功能解剖学。

DESCRIPTION: (Adapted from the Investigator's Abstract) In tactile object recognition we attend to and remember selected features sequentially touched while integrating the information leading to recognition. To understand this complex process we propose using whole-brain functional magnetic resonance imaging (fMRI) in humans and single neuron recording studies in monkeys, who are trained on tactile memory tasks, to investigate the functional anatomy of the sensory and cognitive processes underlying tactile attention and memory. We propose five interrelated fMRI experiments that will determine: (a) the extent of primary somatosensory cortex dedicated to selective activation of the receptors in each fingertip (Exps 1-2), (b) the network of cortical areas engaged by the cognitive processes of tactile attention (Exps 3-4), and (c) the network associated with tactile memory (Exp 5). The first two experiments test the hypothesis that attention involves dynamic modulation of recorded somatotopic maps. The second two experiments focus on the nature of the functional anatomy engaged by attention to the stimulus attributes of vibration frequency, surface roughness and tactile stimulus duration. The fifth experiment examines the functional anatomy engaged during a working memory task for vibration frequency. Overlapping foci identified in Exps 3-5 will suggest a possible network for tactile object recognition because these regions will be common to memory and attention processes. Two neurophysiology studies (Exps 6a, 6b) will record the neural correlates of sensory and working memory in frontal and somatosensory cortex, areas likely to be identified in the fMRI studies. Thus, these observations of single neurons will show differential activity during delay intervals for remembered tactile stimuli and, therefore, highlight the likely temporal dynamics underlying the functional anatomy in the human studies.