UPCI CANCER EDUCATION AND CAREER DEVELOPMENT PROGRAMS

我们建议在癌症的早期发现和预防方面发展一个跨学科的博士后培训计划。我们提议的癌症教育和职业发展(CEcD)计划的总体目标是增加有资格进行跨学科癌症转化性研究的年轻科学家的数量。我们的CECD项目还将提供初步的职业发展，以促进他们过渡到独立调查人员。我们已经组建了一个多学科的导师团队，为这个项目进行教学、实验室和基于人群的研究培训。它将由四部分组成：L)为期四个学期的生物统计学、癌症生物学和生物标记物、流行病学和人类遗传学的具体课程教学，包括完成公共卫生硕士学位；2)专门用于严格的研究培训和早期癌症检测或预防的项目；3)准备K22 NCI过渡职业奖的申请；以及4)职业发展。已经开发了一门关于癌症生物标记物和分子流行病学的专门课程，它将在这一应用的重点领域提供跨学科的指导。该计划将设在匹兹堡大学癌症研究所(UPCI)，培训集中在最近资助的NCI早期检测研究网络生物标记物开发实验室(EDRN/BDL)。我们预计将招募七名研究员加入该计划，他们将完成基础生物医学科学方面的博士水平培训。招聘将在国家层面上进行，利用期刊和全国会议广告、基于网络的资源以及与EDRN调查人员的互动，然后进行个人面试，以确定对转化性癌症研究有职业承诺的最强大的候选人。UPCI的全面临床和研究资源，以及UPCEDRN/BDL活动所强调的资金雄厚的教师导师的支持，共同为这些急需的跨学科科学家提供理想的博士后培训和职业发展环境，以改进癌症的早期发现和预防。

We propose to develop an interdisciplinary postdoctoral training program in early detection and prevention of cancer. The overall goal of our proposed Cancer Education and Career Development (CECD) program is to increase the number of young scientists who are qualified to conduct interdisciplinary translational cancer research. Our CECD program will also provide initial career development to facilitate their transition to independent investigators. We have assembled a multidisciplinary team of mentors to carry out didactic, laboratory, and population-based research training for this program. It will consist of four components: l) four semesters of program-specific didactic instruction in biostatistics, cancer biology and biomarkers, epidemiology, and human genetics, including completion of a MPH degree; 2) time devoted exclusively to rigorous research training and a project in early cancer detection or prevention; 3) preparation of a K22 NCI Transition Career Award application; and 4) career development. A specialized course has been developed in Cancer Biomarkers and Molecular Epidemiology which will provide interdisciplinary instruction in the focus area of this application. This program will be based in the University of Pittsburgh Cancer Institute (UPCI) with training concentrated within the recently funded NCI Early Detection Research Network Biomarkers Developmental Laboratory (EDRN/BDL) of the UPCI. We anticipate recruiting seven Fellows into the program who will have completed doctoral level training in a basic biomedical science. Recruitment will be undertaken on a national level utilizing journal and national meeting advertisements, web-based resources, and interactions with EDRN investigators, followed by personal interviews to identify the strongest candidates with career commitment to translational cancer research. The comprehensive clinical and research resources of the UPCI, the support of the well-funded faculty mentors highlighted by the activities of the UPCI EDRN/BDL, together provide an ideal environment for postdoctoral training and initial career development of these critically needed interdisciplinary scientists to improve cancer early detection and prevention.