FASEB Research Conference on Biological Methylation

说明(由申请人提供)本提案申请部分资金用于 “生物甲基化”研讨会将于二零零一年七月二十一日至二十六日在 佛蒙特州萨克斯顿河的佛蒙特州学院。这将是第五次 关于这一专题的两年期会议，该会议是由 美国实验生物学学会联合会。这个 生物甲基化会议的独特之处在于其综合治疗 ADOMet依赖的甲基转移酶，生物过程受 甲基化和ADOMet代谢。新的甲基转移酶正在被 随着基因组学数据的获得，鉴定的速度正在加快 已确定的甲基转移酶底物现在包括DNA、RNA、 蛋白质、脂质和大量的有机小分子。因为. DNA甲基化对基因表达调控的重要性 染色体稳定性，大约一半的会议是 着重于DNA甲基化的各个方面，特别强调其在 致癌。其他主题包括蛋白质甲基转移酶，结构 甲基转移酶、ADOMet代谢和药物设计的研究。这次会议 参加会议的有来自不同领域的初级和资深科学家 学术、临床和工业机构。这次会议的一个主要目标 是促进研究特定甲基化的科学家之间的互动 在分子、细胞和生理水平上的反应。这次会议 形式包括六次全体会议(24名发言者)和一系列八次会议 正式小型会议(24名发言者)。演讲者包括已建立的和 初级调查员。每一次全体会议将包括一份专家概述 选定的主题和三个演讲因其新颖性和高度而被选中 对赛场的影响。迷你符号的设计具有更多的限制性焦点 关于前沿或有争议的话题。最后一晚将包括一场 主持讨论环节，选定由小组演示的海报 高级调查员。海报将持续在 会议以最大限度地发挥非正式互动和讨论的潜力 与会者之间的数据。2001年的会议预计将吸引140-150人参加。 科学家，主要来自国内机构。

DESCRIPTION (provided by applicant) This proposal requests partial funding for a conference on "Biological Methylation" to be held from July 21-26, 2001, at the Vermont Academy in Saxtons River, Vermont. This will be the fifth biennial conference on this topic, which is held under the auspices of the Federation of American Societies for Experimental Biology (FASEB). The Biological Methylation Conference is unique in its integrative treatment of AdoMet-dependent methyltransferases, biological processes affected by methylation, and AdoMet metabolism. New methyltransferases are being identified at accelerating rates as genomics data becomes available, and identified substrates for the methyltransferases now include DNA, RNAs, proteins, lipids and a large number of small organic molecules. Because of the importance of DNA methylation to the control of gene expression and chromosomal stability, approximately half of the meeting's sessions are focused on aspects of DNA methylation, with particular emphasis on its role in carcinogenesis. Other topics include protein methyltransferases, structural studies of methyltransferases, AdoMet metabolism and drug design. The meeting is attended by a diverse group of junior and senior scientists from a range of academic, clinical and industrial institutions. A major goal of the meeting is to promote interactions between scientists studying particular methylation reactions at the molecular, cellular and physiological levels. The conference format includes six plenary sessions (24 speakers) and a series of eight less formal minisymposia (24 speakers). Speakers include both established and junior investigators. Each plenary session will include an expert overview of the selected topic and three presentations selected for their novelty and high impact on the field. Minisymposia are designed with a more restrictive focus on cutting-edge or controversial topics. The last evening will include a moderated discussion session of posters selected for presentation by a panel of senior investigators. Posters will be displayed continuously at the meeting to maximize the potential for informal interactions and discussion of data between the attendees. The 2001 meeting is expected to attract 140-150 scientists, largely from domestic institutions.