Non Antibiotic Properties of Tetracycline

本申请是对将于2001年7月1日至6日在新伦敦的科尔比索耶学院举行的题为“四环素和其他抗生素的非抗生素性质”的多学科会议的补充支持的请求。在戈登研究会议协会的主持下举行的这次会议将是第二次关于一个独特而令人兴奋的主题的会议，涵盖了一类四环素衍生化合物和其他抗生素的基础和临床应用。自Golub等人于1983年首次报道以来，四环素类（TC）和化学修饰的非抗微生物四环素类（CMT）的非抗生素性质已在生物医学研究的不同领域中得到应用。其中包括：作为tet-on和tet-off基因构建体的诱导剂的活性，用于体内和体外基因表达研究、牙周病的治疗（Periostat FDA 1998年批准）、癌症、关节炎、急性呼吸窘迫综合征（ARDS）、舍格伦综合征和其它干眼病的潜在治疗，以及作为中风的早期治疗。所有这些应用都是基于TC的抗金属蛋白酶（MMP）和抗炎特性。以前关于这个新主题的会议已经在生物医学界产生了巨大的兴趣，压倒性的80%以前的与会者都表示希望参加即将举行的会议。来自美国和欧洲的科学家名单，包括已建立的工作人员和新进入该领域的人员，已同意介绍和分享他们最近关于TC和其他抗生素的非抗生素特性及其在疾病治疗中的应用的工作。会议将重点交流有关TC研究的有前途的生物模型，作用的分子机制和TC的药理学的新信息，重点是癌症，在8个密集的谈话和讨论会议加上5个会后聚会。会议预计将通过促进合作和建立一个讨论未来研究方向的论坛，对这一迅速兴起的领域产生重大影响。

This application is a request for supplemental support for a multidisciplinary conference entitled "Non-Antibiotic Properties of Tetracyclines and Other Antibiotics" to be held at Colby Sawyer College, New London, CT during the week of July 1-6, 2001. This meeting held under the auspices of the Gordon Research Conference Society will be the second of its kind on a unique and exciting topic, covering both basic and clinical applications of a class of tetracycline derived compounds and other antibiotics. Since first reported in1983 by Golub et al., the non-antibiotic properties of tetracyclines (TCs) and chemically modified non-antimicrobial tetracyclines (CMTs) have found applications in diverse areas of biomedical research. These include: activity as an inducer of tet-on and tet-off gene constructs for in vivo and in vitro gene expression studies, treatment of periodontal disease (Periostat FDA approved 1998), a potential treatment for cancer, arthritis, acute respiratory distress syndrome (ARDS), Sjogrens syndrome and other dry eye diseases, and as an early treatment for stroke. All these applications are based on the anti-metalloproteinase (MMP) and anti-inflammatory properties of TCs. Previous meetings on this novel topic have generated in the biomedical community such immense interest that an overwhelming 80% of the previous attendees have responded with their desire to attend the upcoming meeting. A roster of scientists from the US and Europe, both established workers and those new to the field, have agreed to present and share their recent work on the non-antibiotic properties of TCs and other antibiotics and their application to the treatment of disease. The conference will focus on the exchange of new information regarding promising biological models of TC investigation, the molecular mechanism of action and the pharmacology of TCs with an emphasis on cancer, in 8 intensive talk and discussion sessions plus five after session gatherings. The conference is expected to have a significant impact on this rapidly emerging field by fostering collaborations and establishing a forum for discussion regarding the direction of future research.