Gordon Research Conference of Polyamine

多胺是一种小的阳离子烷基胺，对细胞的生长和存活是绝对必要的。主要的、自然存在的多胺、亚精胺和精胺及其二胺前体腐胺通过高度调节的代谢系统维持在较高的细胞内浓度。细胞内的多胺水平也受到高度特异的、能量依赖的多胺运输系统的部分调节。人们对多胺及其代谢途径有相当大的兴趣，因为许多病理状态都伴随着多胺代谢的改变和多胺水平的增加，包括肿瘤疾病。随着人们对多胺分子作用认识的迅速加深，干扰多胺代谢和功能的药物的开发也取得了长足的进步。这些药物已显示出作为治疗剂和工具的前景，以增加对原核和真核细胞中多胺功能的了解。目前提案的目的是为一年两次的戈登多胺会议获得部分资金。拟议的会议将为高级和初级研究人员之间自由交流信息和新想法提供一个极好的环境，这些信息和新想法将涵盖广泛的兴趣，包括基础科学到临床应用。即将举行的会议的议程将包括代表该领域最新和最有影响的进展的主题范围。即将召开的2001年戈登多胺会议的正式会议议题将包括：多胺在细胞周期调节和细胞死亡中的作用、分子水平上多胺代谢的调节、转基因模型在多胺参与疾病过程研究中的使用、真核细胞中的多胺运输、多胺作为化疗和化学预防癌症靶标的干扰。

Polyamines are small cationic alkylamines that are absolutely necessary for cell growth and survival. The predominant, naturally occurring polyamines, spermidine and spermine and their diamine precursor, putrescine are maintained at high intracellular concentrations by a highly regulated metabolic system. The intracellular level of polyamines is also partially regulated by a highly specific, energy-dependent, polyamine transport system. There is considerable interest in the polyamines and their metabolic pathway because many pathological states are accompanied by an alteration in polyamine metabolism and increased polyamine levels, including neoplastic diseases. The rapid increase in the understanding of the molecular roles of the polyamines has led to considerable advances in the development of agents to interfere with polyamine metabolism and function. These agents have shown promise as therapeutic agents and as tools to increase the understanding of polyamine function in prokaryotic and eukaryotic cells. The purpose of the current proposal is to obtain partial funding for the biannual Gordon Conference on Polyamines. The proposed conferences will provide an excellent environment for the free exchange of information and new ideas among senior and junior investigators that will encompass a wide spectrum of interests including basic science to clinical applicability. The range of topics to be included in the programs for the upcoming meetings will be those that represent the most recent and impacting advances in the field. The formal session topics for upcoming 2001 Gordon Conference on Polyamines will include: The role of polyamines in cell cycle regulation and cell death, regulation of polyamine metabolism at the molecular level, the use of transgenic models in the study of polyamine involvement in disease processes, polyamine transport in eukaryotic cells, interference of polyamine function as a target for chemotherapy and chemoprevention in cancer.