FASEB Conference on Ubiquitin and Protein Degradation

“泛素和蛋白质降解”会议将于2001年6月23日至28日在佛蒙特州萨克斯顿河佛蒙特学院会议中心举行。该会议由美国实验生物学学会联合会（FASEB）赞助和部分资助，自1989年以来每两年举行一次。这次会议是唯一定期举行的会议，主要致力于泛素的生物学和生物化学。本申请请求为2001年会议提供部分资金。这种保守的蛋白质泛素，以及许多作用于泛素的酶，在真核生物中是必不可少的。泛素的生物学功能需要通过一系列泛素偶联酶将其共价附着在细胞蛋白上。对这种修饰的最好研究和理解的结果是一个信号，该信号针对泛素修饰的蛋白质，通过大型蛋白酶复合物26S蛋白酶体进行atp依赖性降解。泛素系统对蛋白质的选择性降解现在被认为是一种通过调节这些过程所需的关键蛋白质水平来控制许多细胞过程的共同机制。这些过程包括细胞周期、转录、通过代谢途径的底物通量、发育和抗原加工。除蛋白酶体降解外，泛素化还可参与其他过程，如膜受体内化。这些新奇的过程才刚刚开始被理解。此外，最近的工作已经确定了一组与泛素结构相似的蛋白质。这些蛋白质的代谢过程与泛素的代谢过程相似，但又不同。这些分子似乎作为共价信号，将其独特的底物靶向到细胞内的特定位置。这些议题将在2001年会议的九个科学会议上讨论。将有七次例会，每次由六名受邀演讲组成，两次特别会议，每次由从提交的摘要中选出的七场演讲组成。后一份报告的选择将特别考虑到女性和年轻的研究者，异常重要的最新发现，以及新的参与者。除了平台展示之外，还将有两个海报环节，这是本次会议历史上活跃且有益的一部分。会议的规模小，地点和形式都是为了促进175名参与者之间的最大互动而设计的。

The Conference, "Ubiquitin and Protein Degradation" will be held from June 23-28, 2001, at the Conference Center of the Vermont Academy in Saxton's River, VT. This conference is sponsored and partially funded by the Federation of the American Societies for Experimental Biology (FASEB) and has been held biannually since 1989. This conference is the only regularly held meeting devoted primarily to the biology and biochemistry of ubiquitin. This application requests partial funding for the 2001 conference.The conserved protein ubiquitin, and many of the enzymes that act upon and with it, are essential in eukaryotes. The biological functions of ubiquitin require its covalent attachment to cellular proteins by a cascade of ubiquitin-conjugating enzymes. The best-studied and understood consequence of this modification is that of a signal which targets ubiquitin-modified proteins for ATP-dependent degradation by a large protease complex, the 26S proteasome. The selective degradation of proteins by the ubiquitin system is now recognized as a common mechanism for control of many cellular processes by regulating the level of critical proteins required for those processes. Such processes include the cell cycle, transcription, flux of substrates through metabolic pathways, development, and antigen processing. Ubiquitinylation can also be involved in fates other than proteasomal degradation, such as membrane receptor internalization. These novel processes are only beginning to be understood. Moreover, recent work has identified a set of proteins with structural similarities to ubiquitin. These proteins undergo a metabolism which is parallel to, but distinct from, that of ubiquitin. These molecules appear to function as covalent signals that target their unique substrates to specific locations with within she cell. These topics are among those to be addressed in the nine scientific sessions of the 2001 Conference. There will be seven regular sessions, each consisting of six invited presentations, and two special sessions, each consisting of seven talks selected from submitted abstracts. The latter presentations will be chosen with special consideration for women and younger investigators, unusually important recent findings, and new participants. In addition to the platform presentation, there will be two poster sessions, a historically active and beneficial part of this conference. The small size of the conference, and its location and format are designed to foster maximal interactions among the 175 participants.