CONFERENCE ON MACROPHAGE ACTIVATION AND DEACTIVATION

描述：(改编自申请者摘要) 巨噬细胞在先天性和获得性免疫反应中的作用已被认识到 有一段时间了。最近清楚的是，这种免疫反应也 在巨噬细胞激活和功能的调节中起关键作用， 通过巨噬细胞受体与补体激活产物的结合， 趋化因子、促炎和抗炎细胞因子、免疫球蛋白和配体 在激活的T细胞上。此外，越来越明显的是，监管失衡 病原体介导的巨噬细胞激活和功能颠覆至关重要 到各种疾病的发病机制，如败血症、麻疹、利什曼病、艾滋病 哮喘和器官特异性自身免疫性疾病。对这一问题的理解 巨噬细胞活化及其效应调控的分子基础 近年来，机制取得了快速发展。没有举行任何会议 利用最近知识的爆炸性增长。这次会议的目标是 因此，要回顾对双向影响的了解状况 巨噬细胞对天然免疫和获得性免疫的激活和失活 回应。 目前这一领域的发酵在许多方面都不是经典的 巨噬细胞生物学的研究热点。通过将临界质量的 多学科研究人员，这次研讨会应该提供一个理想的论坛 为深入揭露初级调查人员(研究生和 博士后)到一个快速发展、富有成果的免疫生物学研究领域，如 以及吸引这样的科学家进入这一领域。研讨会正在进行中 与《先天与习得之间的接口》一书同时举行 豁免权。“

DESCRIPTION: (Adapted from Applicant's Abstract) The central role of macrophages in both innate and acquired immune responses has been appreciated for some time. It has recently become clear that such immune responses also play key roles in the regulation of macrophage activation and function, through engagement of macrophage receptors for complement activation products, chemokines, pro- and anti-inflammatory cytokines, immunoglobulins, and ligands on activated T cells. Further, it is becoming evident that dysregulation of pathogen-mediated subversion of macrophage activation and function is critical to pathogenesis in diseases as varied as sepsis, measles, leishmaniasis, AIDS, asthma, and organ-specific autoimmune diseases. The understanding of the molecular basis for the regulation of macrophage activation and effector mechanisms has made rapid progress in recent years. No meeting has taken advantage of this recent explosion in knowledge. The goal of this meeting is thus to review the state of knowledge of the bi-directional effects of macrophage activation and deactivation on innate and acquired immune responses. The current ferment in the field is, in many ways, outside the classical preoccupations of macrophage biology. By bringing together a critical mass of multidisciplinary researchers, this symposium should provide an ideal forum both for the in-depth exposure of junior investigators (graduate students and post-docs) to a fast-moving, fruitful area of immunobiological research, as well as for enticing such scientists into the field. The symposium is being held in conjunction with one on "Interfaces between Innate and Adaptive Immunity."