MRI UPGRADE:BIDMC CENTER FOR BASIC MR RESEARCH

以色列贝丝女执事医疗中心(BIDMC)放射科的基础磁共振研究中心包含一套Bruker BIOSPEC系统和一套Bruker DRX系统。这些工具目前是集成的，并由一大批NIH资助的研究人员以及为未来NIH资助进行先导研究的其他调查人员交互使用。这项提议的目的是提升该中心的核磁共振成像能力，以便为使用该中心的大量NIH资助的调查人员提供最先进的设施。我们特别要求：1.将BIOSPEC射频电子设备从基于MSL的电子设备升级到基于Avance的电子设备。2.BIOSPEC的射频屏蔽室升级为射频/钢屏蔽室。3.DRX硬件的升级，包括将显微成像探头升级到Micro 2.5，以及数字化仪和相位相干DDS选项。Avance升级将确保比目前已有12年历史的MSL电子产品更高的可靠性、信噪比和更快的成像能力。射频/钢屏蔽室将使磁体从目前的2T场强提高到4.7T，从而提高信噪比，从而提高所有研究的分辨率。Micro2.5探头将取代原来的未屏蔽的10年前的显微成像探头。这种新的探头将提高梯度切换、成像速度，并将显著改善在体鼠的成像。同样，升级后的数字化仪将实现更快的成像和更简单的脉冲编程。拟议的升级将支持来自5个不同机构10个部门的18名调查员的21个项目。目前有14个项目得到了NIH的资助，另外4个项目的NIH申请目前正在审查中。

The Center for Basic MR Research at the Radiology Department of Beth Israel Deaconess Medical Center (BIDMC) contains a Bruker BIOSPEC system and a Bruker DRX system. These instruments are currently integrated and are used interactively by a large group of NIH funded investigators, as well as other investigators pursuing pilot studies for future NIH funding. The purpose of this proposal is to upgrade the MRI capabilities of the Center in order to have a state-of-the-art facility for the large number of NIH funded investigators who utilize it. In particular, we are requesting: 1. An upgrade of the BIOSPEC rf electronics from MSL based electronics to Avance based electronics. 2. An upgrade of the rf shielded room of the BIOSPEC to an rf/steel shielded room. 3. An upgrade of the DRX hardware, including an upgrade of the microimaging probe to the micro 2. 5 and the digitizer and phase coherent DDS option. The Avance upgrade will ensure enhanced reliability, signal to noise, and faster imaging capabilities than the current 12 year old MSL electronics. The rf/steel shielded room will enable the magnet to be ramped up to 4.7 T from the present 2 T field strength, increasing the signal to noise and hence resolution of all studies. The micro2.5 probe will replace the original unshielded 10 year old microimaging probe. This new probe will increase gradient switching, imaging speed, and will significantly improve in vivo mouse imaging. Similarly, the upgraded digitizer will enable faster imaging and simpler pulse programming. The proposed upgrade will support 21 projects from 18 investigators at 10 departments in 5 different institutions. 14 projects are currently NIH funded, and 4 others have NIH applications currently under review.