Thermoregulatory Sequela of Traumatic Brain Injury

描述：(申请人提供)本实验的目的是 描述创伤后体温升高(PTH)的动物模型，以便 未来的干预性研究可能会进行，然后翻译给患者 关心。甲状旁腺功能亢进是一种影响高达37%的 中-重度颅脑损伤(TBI)。它已经被很好地记录下来了 损伤后体温过高会恶化缺血和缺氧动物模型的预后。 TBI。体温过高会增加新陈代谢支出，导致不能 来维持肌肉或脂肪的储存。肌肉损失可能会显著 延长恢复到最大功能所需的时间。此外，PTH是一种 诊断排除，要求患者接受多项检查 昂贵而痛苦的诊断测试。这种诊断上的延迟也会推迟 开始适当的治疗，因为传统的发烧干预措施 无效，并可能延迟转移到康复。到目前为止，研究已经 仅仅是为了确定发病率，因此对 甲状旁腺激素现象。侧方甲状旁腺激素动物模型的建立 流体冲击损伤将提供关于这种后遗症的必要知识， 尤其是关于温度在损伤后即刻的影响 诱导甲状旁腺激素的后续发展阶段。甲状旁腺激素对血管紧张素转换酶的影响 行为和认知也将在这项探索性研究中得到检验。 此外，这项研究的结果将提供有关 铜、锌和α-1三种急性相反应物的关系 抗胰酶，甲状旁腺激素，以确定其作为生物标志物的潜在用途。

DESCRIPTION: (provided by applicant) The goal of this experiment is to characterize an animal model of post-traumatic hyperthermia (PTH) in order that future interventional studies may be undertaken and then translated to patient care. PTH is a condition that affects up to 37% of patients with moderate-severe traumatic brain injuries (TBI). It has been well documented that hyperthermia post-injury worsens outcome in animal models of ischemia and TBI. Hyperthermia increases metabolic expenditure, resulting in the inability of patients to maintain muscle or fat stores. Muscle loss can significantly extend the time required to return to maximal function. Additionally, PTH is a diagnosis of exclusion, requiring the patient to be subjected to multiple costly and painful diagnostic tests. This delay in diagnosis also delays initiation of appropriate treatment as traditional interventions for fever are ineffective, and can delay transfer to rehabilitation. To date, studies have been aimed solely at determining incidence, thus very little is known about the phenomenon of PTH. The development of an animal model of PTH using lateral fluid percussion injury would provide needed knowledge about this sequela, particularly regarding the effect of temperature in the immediate post injury phase on inducing the subsequent development of PTH. The effect of PTH on behavior and cognition will also be examined in this exploratory study. Additionally, the findings of this study will provide information on the relationship of three acute phase reactants, copper, zinc, and alpha-1 antitrypsin, to PTH to determine their potential use as biological markers.