Novel 125I Uniformly Distributed Ophthalmic Plaques

描述(摘自申请人的摘要)： 近距离放射治疗种子眼斑是眼科治疗中常用的方法。 黑色素瘤和黄斑变性。除了体积相对较大外， 种子芯产生的剂量分布不均匀且高度集中 很复杂。利用每个种子的非球形等剂量辐射分布和 在个体种子活动的变异中，它是一个极其复杂和 精确计算变化情况下辐射剂量率的困难过程 在眼睛里，甚至在肿瘤里。 提出了一种新的均匀分布的放射性斑块的方案 捏造的。斑块应由注入125I离子的薄箔组成。 安装在0.5毫米厚的金色防护罩上。金盾也将 充当辐射准直器，以保护位于 斑块的外围。将使用隔离器来密封放射源。 这块斑块将提供准确的辐射剂量测定，并将是 比现在的眼斑还薄。使用这种斑块的肿瘤照射计划 会优化对肿瘤的剂量，同时最大限度地减少对正常眼睛的剂量 结构导致辐射引起的眼部显著减少 并发症。 建议的商业应用：不可用

DESCRIPTION (From the Applicant's Abstract): Brachytherapy seed eye plaques are commonly used in the treatment of ocular melanomas and macular degeneration. In addition to being relatively bulky, the dose distribution generated by the seed cores is non-uniform and highly complex. With the non-spherical iso-dose radiation profiles of each seed and variations in individual seed activities, it is an extremely involved and difficult process to accurately calculate the radiation dose rate at varying points within the eye and even within the tumor. A plan is proposed in which a novel uniformly distributed radioactive plaque is fabricated. The plaque shall consist of an 125I ion implanted thin foil attached to a 0.5 mm thick gold protective shield. The gold shield shall also act as a radiation collimator to protect normal structures located at the periphery of the plaque. A spacer will be used to seal the radioactive source. This plaque would provide accurate radiation dosimetry and would be three times thinner than current eye plaques. Tumor irradiation plans using such a plaque would optimize the dose to the tumor while minimizing the dose to normal ocular structures resulting in an significant decrease in radiation induced ocular complications. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE