Automatic Metaphase Spread Finder using Novel ScanScope

描述(申请人提供)：手动幻灯片扫描是最常用的方法之一 细胞遗传学分析的繁琐和耗时的要素。最新进展 一种新的自动数字扫描技术，称为 ScanScope，是为了高效地在一个 细胞遗传学显微镜载玻片的制备。ScanScope方法基于 快速扫描和数字化整个显微镜幻灯片-高达30次 比传统方法更快-随后创建了大型 一种连续的数字图像，它是查找中期扩展的基础。 初步结果证明了这种新方法的潜力。 适用于自动查找中期扩散的图像。我们 建议进一步研究和优化细胞遗传学快速扫描 显微镜样品和图像处理算法的发展，从而 最终提供了一种经济高效的方法来寻找中期传播， 是快速和全自动的，但足够可靠，适合日常工作 临床应用。软件算法的开发是为了说明这一点 这种改进的自动和可靠查找方法的可行性 中期在各种细胞遗传学制剂中传播。 建议的商业应用： 拟议的中期扩散自动搜索器将消除手动载玻片扫描，这是细胞遗传学分析中最繁琐和耗时的元素之一。ScanScope的新功能预计将使快速、全自动和可靠的仪器开发具有成本效益，适用于约1000个潜在地点的常规临床使用。临床实验室预计会迅速采用，因为使用ScanScope中期扩散搜索器可以提高生产率，回收期不到12个月。

DESCRIPTION (provided by applicant): Manual slide scanning is one of the most tedious and time-consuming elements of cytogenetic analysis. The development and application of a new automated digital scanning technology, termed ScanScope, is proposed for efficiently finding all metaphase spreads in a cytogenetic microscope slide preparation. The ScanScope approach is based on rapidly scanning and digitizing an entire microscope slide - up to 30 times faster than conventional approaches - followed by the creation of a large contiguous digital image that is the basis for finding metaphase spreads. Preliminary results demonstrate the potential of this novel method to yield images that are suitable for automatically finding metaphase spreads . We propose to further study and optimize the rapid scanning of cytogenetic microscope samples and the development of image processing algorithms, so as to ultimately provide a cost-effective method for finding metaphase spreads that is rapid and fully automatic, yet reliable enough to be suitable for routine clinical use. The development of software algorithms is proposed to demonstrate the feasibility of this improved method for automatically and reliably finding metaphase spreads in a variety of cytogenetic preparations. PROPOSED COMMERCIAL APPLICATIONS: The proposed automatic metaphase spread finder will eliminate manual slide scanning, one of the most tedious and time-consuming elements of cytogenetic analysis. The novel features of the ScanScope are expected to enable the cost-effective development of a rapid, fully automatic and reliable instrument that is suitable for routine clinical use at some 1000 potential sites. Rapid adoption by clinical laboratory is expected because productivity increases resulting from use of a ScanScope metaphase spread finder translate into payback periods less than 12 months.