Biochemical Detection with Single-Electron Transistors

描述：（由申请人提供）本申请描述了扩展 单电子晶体管（SET）的生物化学检测。Theses装置 对甚至单分子结合事件都很敏感， 动力.它们采用标准硅微机械加工技术制造， 生产迅速，成本低廉，易于适应特定的 应用要求。本项目将展示其在监测 生物素/链霉亲和素的偶联，以及DNA寡聚体杂交， 为了证明SET在生物研究中的有效性， （微阵列）、医学诊断和生化战防御。 拟定商业应用： 该设备将在床旁医疗领域具有商业潜力 诊断学、生物学研究、基因组学和生化战防御。

DESCRIPTION: (provided by applicant) This application describes the extension of single-electron transistors (SET's) to biochemical detection. Theses devices are sensitive to even single-molecular binding events and use very little power. Fabricated with standard silicon micromachining techniques, they are rapidly and inexpensively produced, and easily adaptable to specific application requirements. This project will demonstrate their use in monitoring the coupling of biotin/steptavidin, as well as DNA oligomer hybridization in order to demonstrate the effectiveness of SET's for biological research (microarrays), medical diagnostics, and biochemical warfare defense. PROPOSED COMMERCIAL APPLICATION: This device will have commercial potential in the areas of point-of-care medical diagnostics, biological research, genomics, and biochemical warfare defense.