Electrophoretic deposition of tough films for suture tear resistance

电泳沉积是一种广泛使用的技术，用于快速生产一系列材料的涂层，包括金属，陶瓷和聚合物。该技术是有利的，因为它的高速度，高纯度的沉积材料，并用于生产完全均匀厚度的层。最近，研究已经尝试使用EPD来制造可用于一系列医疗目的的生物材料膜。本项目的目的是开发一种有效的和可重复的方法，用于电泳沉积胶原蛋白，以快速制造任意尺寸的膜。将开发这些基于胶原蛋白的膜，使其具有合适的机械性能，以在缝合时抵抗撕裂，并将评估膜的生物相容性，以确定允许细胞原位生长的适用性。进一步的工作将旨在开发具有命令集交联剂的多层膜，希望创造一种可以在手术实践中由医疗专业人员轻松成形和固定的膜。

Electrophoretic deposition is a widely used technique to rapidly produce coatings for a range of materials including metals, ceramics, and polymers. The technique is advantageous because of its high speed, high purity of deposited material, and for producing layers of completely uniform thickness. More recently, research has attempted to use EPD for the fabrication of biomaterial films that can be used for a range of medical purposes. The aim of this project is to develop an effective and reproducible method for electrophoretic deposition of collagen to rapidly manufacture films of arbitrary dimensions. These collagen-based films will be developed to have suitable mechanical properties to resist tearing when sutured and the biocompatibility of the films will be assessed for suitability of allowing cell growth in situ. Further work will aim to develop multi-layered films with command-set crosslinking agents, with the hope of creating a film that can be easily shaped and fixed by medical professionals within a surgical practice.