Nutritional influences on lung function

描述（由申请人提供）： 本研究旨在探讨营养因素与肺的关系 功能和慢性阻塞性肺疾病（COPD）。 该项目将 使用三个数据源来研究以下假设。 一是做 抗氧化剂保护肺免受内源性和外源性 氧化剂？ 这个研究问题将通过纵向数据来解决 标准老化研究（NAS）是一项对2,280名男性进行的前瞻性研究。 从食物频率获得的维生素C和E以及β-胡萝卜素的膳食摄入量数据 调查问卷（1987年首次发放）将在以下方面进行审查 随后13年的肺部结局，包括 第一秒呼气量（FEV 1），乙酰甲胆碱气道 反应性和COPD事件。 需要纵向证据来评估 因果关系 其次，低血脂水平是否会增加呼吸道疾病的风险？ 成果？ 将使用三个数据源来解决这个研究问题。 使用第三次全国健康和营养调查的横截面数据， 检查调查，我们将调查血脂（总， LDL和HDL胆固醇;载脂蛋白AI和B）对肺功能和 COPD风险。 脂质与肺功能的关系也将在 在NAS队列中进行了研究。 前瞻性数据允许考虑 具有时间维度的问题，例如血脂谱的变化 预测肺部结果的变化。 最后，横截面数据来自 中国是一个天然低胆固醇的人口，将进行研究， 在不同暴露范围的人群中考虑该假设。 我们还将考虑脂质和抗氧化剂可能的联合作用 暴露对肺部结果的影响，考虑到一些候选抗氧化剂， 例如维生素E和β-胡萝卜素是脂溶性的。 总体目标 了解营养如何影响肺功能，包括绝对的 以及营养如何影响 肺病。 综合研究营养因素的方法， 提出了它们对肺结果的潜在影响。

DESCRIPTION (provided by applicant): This proposal investigates the relation of nutritional factors to lung function and chronic obstructive pulmonary disease (COPD). The project will use three data sources to investigate the following hypotheses. First, do antioxidants protect the lung from damage caused by endogenous and exogenous oxidants? This research question will be addressed with longitudinal data from the Normative Aging Study (NAS), a prospective study of 2,280 men. Dietary intake data on vitamins C and E and betacarotene from food frequency questionnaires (first administered 1987) will be examined in relation to pulmonary outcomes over the subsequent 13-year period, including forced expiratory volume in the first second (FEV1), methacholine airways responsiveness, and incident COPD. Longitudinal evidence is needed to assess causality. Second, do lower lipid levels increase the risk of respiratory outcomes? Three data sources will be used to address this research question. Using cross-sectional data from the Third National Health and Nutrition Examination Survey, we will investigate the relation of lipid profile (total, LDL and HDL cholesterol; apolipoproteins AI and B) to lung function and to prevalent COPD risk. The relation of lipids to lung function also will be investigated in the NAS cohort. The prospective data allow consideration of questions with a time dimension, for example whether changes in lipid profile predict changes in pulmonary outcomes. Finally, cross-sectional data from China, a population with naturally low cholesterol, will be studied to consider the hypothesis in a population with a different range of exposure. We will also consider the possible joint effects of lipids and antioxidant exposures on lung outcomes, given that some of the candidate antioxidants, for example vitamin E and betacarotene, are lipid-soluble. The overall objectives are to understand how nutrition affects lung function, including absolute measures as well as rate of decline, and how nutrition affects the risk of lung disease. An integrated approach to the study of nutritional factors and their potential influences on lung outcomes is proposed.