FINE MAPPING OF CROHNS DISEASE LOCUS ON CHROMOSOME 16:INFLAMMATORY BOWEL DISEASE

脑血管疾病是导致死亡的第三大原因 在美国，大约四分之一的心血管死亡是由于破裂 颅内动脉瘤(IA)。在那些在破裂中存活下来的人中，超过 一半的人患有神经缺陷。择期手术和 破裂前的治疗对预防发病率非常有效。 和死亡率。及早识别感染IA的易感个体 因此将大大增强我们防止最严重的 结果。49例受累同胞的基因组扫描初步分析 PARAY已经完成。多个候选区域(一个带有LOD Score&gt；2.5)已被牵连。我们目前正在进行基因分型 原始49对候选区域中的附加标记 以及附加的一组配对，以尝试确认与一个配对的链接 或更多这样的地区。

Cerebrovascular (CV) disease is the third leading cause of death in the U.S. and about one-quarter of the CV deaths are due to ruptured intracranial aneurysms (IA). Of those that survive rupture, more than half are left with neurological deficits. Elective surgery and treatment prior to rupture are very effective in preventing morbidity and mortality. Early identification of individuals susceptible to IA would therefore greatly enhance our ability to prevent most serious outcomes. Preliminary analysis of a genome scan of 49 affected sib pairs has been completed. Several candidate regions (one with lod score > 2.5) have been implicated. We are currently genotyping additional markers in these candidate regions on the original 49 pairs and an additional set of pairs in an attempt to confirm linkage to one or more of these regions.