Consortium/Molecular and Cell Biology of NF1 and NF2

描述（由申请人提供）： 要求提供资金以支持将于2002年6月9日至12日在科罗拉多白杨的杰罗姆酒店举行的NF1和NF2分子和细胞生物学国家神经纤维瘤病基金会国际联盟的下一次会议。 从1985年的第一次会议开始，这些会议已经成为许多基本发现的催化剂，这些发现为这些重要的神经系统疾病提供了重要的见解。这些会议提供了一个定期论坛，汇集了细胞生物学家，遗传学家，临床医生和其他熟悉NFI和NF2的人，分享他们的最新研究成果和经验。NNFF联盟在NF1和NF2分子理解的快速发展中发挥了重要作用，包括克隆相关基因、建立诊断测试、探索蛋白质功能、开发动物模型以及创建患者和临床医生网络以促进临床试验。2002年联合会会议是一次公开会议，将向广大科学界宣传。六场平台会议的每一场都将由两名该领域的专家共同主持，他们将指导对所介绍的工作及其与整个会议主题的相关性的讨论。这些会议还将包括来自NF研究社区的特邀演讲者和从提交的摘要中选择的其他演讲。将鼓励初级调查员参加会议，组织者预计，根据以往联合会会议的情况，发言者中将有相当大比例的年轻调查员。将指示发言者留出时间供所有与会者进行公开讨论。此外，六位主题演讲者的长篇演讲将被纳入科学会议，他们是与NF研究直接相关的科学领域或新兴技术的领导者。还将举行两次海报会议，使研究者能够提交未被选入其中一次口头会议的摘要。除了更新NFI和N'F2研究人员的最新研究进展外，本次会议将有助于确定我们知识中的关键差距以及解决这些问题的战略和合作。对NF1和NF2的分子基础的更好理解将在开发针对这些疾病的并发症的改进疗法中发挥重要作用，并对发育神经生物学和癌症研究领域具有广泛的影响。

DESCRIPTION (provided by applicant): Funding is requested to support the next meeting of the National Neurofibromatosis Foundation International Consortium for the Molecular and Cell Biology of NF1 and NF2 to be held June 9-12, 2002 at the Hotel Jerome in Aspen, Colorado. Beginning with the first meeting in 1985, these conferences have served as the catalysts for many of the fundamental discoveries that have contributed major insights into these important diseases of the nervous system. These meetings provide a regular forum to bring together cell biologists, geneticists, clinicians, and others familiar with NFI and NF2 to share their latest research findings and experiences. NNFF Consortia have been instrumental in the rapid advances in the molecular understanding of NF1 and NF2, including the cloning of the responsible genes, establishment of diagnostic tests, exploration of protein function, development of animal models, and creation of a network of patients and clinicians to facilitate clinical trials. The 2002 Consortium meeting has been organized as an open meeting that will be advertised to the general scientific community. Each of six platform sessions will be co-chaired by two experts in the field who will guide discussion of the presented work and its relevance to the overall session topic. These sessions will also include invited speakers from the NF research community and other presentations to be selected from submitted abstracts. Participation by junior investigators will be encouraged and the organizers anticipate, on the basis of previous Consortium meetings, that a substantial percentage of the speakers will be young investigators. Speakers will be instructed to allow time for open discussion among all participants. In addition, longer talks by six keynote speakers who are leaders in scientific fields or emerging technologies that are directly relevant to NF research will be incorporated into the scientific sessions. Two poster sessions will also be held which will allow investigators to present abstracts that are not selected for one of the oral sessions. In addition to updating investigators working on NFI and N`F2 on the latest research developments, this meeting will help to identify critical gaps in our knowledge as well as strategies and collaborations to address them. An improved understanding of the molecular basis of NF1 and NF2 will play an essential role in developing improved therapies for the complications of these disorders and has broad implications to the fields of developmental neurobiology and cancer research.