Conference on Wiring and Plasticity of Nervous Systems

描述（由申请人提供）：细胞生物学家最近绘制了 信号通路（小GTP酶到WASP/Scar蛋白到Arp 2/3复合物）， 控制肌动蛋白丝的组装， 运动细胞独立地，神经生物学家已经确定了关键的血浆 可溶性和基质分子的膜受体，其引导 神经生长锥的硬布线过程中的目标， 系统，一个产生大约一百万英里神经元的过程， 在人类大脑中的过程！在人的一生中， 对似乎也依赖于肌动蛋白过程的活动作出反应 组装件.尽管细胞生物学家致力于研究细胞运动的机制 研究大脑发育和可塑性的神经科学家 在调查同一进程时，沟通很少。一 神经生物学家评论说：“这些群体很少出现在 同一个房间。“现在是时候举办一次研讨会， 科学家们一起致力于肌动蛋白为基础的运动和发展， 神经系统我们相信，互利的见解将出现 了解彼此的工作。

DESCRIPTION (provided by applicant): Cell biologists recently mapped the signaling pathways (small GTPases to WASP/Scar proteins to Arp2/3 complex) that control the assembly of actin filaments that drives forward the leading edge of motile cells. Independently, neurobiologists have identified key plasma membrane receptors for soluble and matrix molecules that guide the motility of neuronal growth cones to their targets during the hard wiring of the nervous system, a process that produces approximately one million miles of neuronal process in the human brain! Throughout life, synaptic connections are remodeled in response to activity by processes that also appear to depend on actin assembly. Although cell biologists working on mechanisms of cellular motility and neuroscientists working on brain development and plasticity are investigating on the same process, communications have been minimal. One neurobiologist commented that "these groups have rarely if ever been seen in the same room." The time is now opportune for a symposium that will bring together scientists working on both actin-based motility and development of nervous systems. We are confident that mutually beneficial insights will emerge from learning about each others work.