The role of hTRPA1 in Pain Sensation

长期持续和复发性疼痛是世界范围内的主要健康问题，特别是在老龄化人群中。开发新的有效的疼痛治疗方法受到缺乏对引起疼痛感觉的过程的理解的阻碍。此外，还不清楚某些化学品（如防暴剂）为什么会引起疼痛。该项目的作用是确定疼痛感源于蛋白质人类TRPA1（hTRPA1）激活的确切机制，这将有助于了解如何加速疼痛治疗的发展，以及如何更有效地保护人类免受刺激性化学物质的影响。通过进一步了解疼痛及其基本机制，该项目将解决BBSRC生物科学对人类健康和世界级基础生物科学的优先领域。伊布，ENWW

Long lasting and recurrent pain is a major health problem worldwide, especially in aging populations. Developing new and effective treatments for pain is hampered by a lack of understanding of the processes that give rise to the feeling of pain. Furthermore, it is not understood hy certain chemicals (such as riot control agents) cause pain. The role of this project is to ascertain the exact mechanisms by which the feeling of pain originates from activation of the protein human TRPA1 (hTRPA1) which will give insights into how to accelerate the development of treatments for pain and also how to more effectively protect humans from the actions of irritant chemicals. Through furthering the understanding of pain and its fundamental mechanisms, this project will address the BBSRC priority areas of bioscience for human health and world-class underpinning bioscience. IBB, ENWW