2-CHLORODEOXYADENOSINE (2CDA) FOR CHRONIC PROGRESSIVE MULTIPLE SCLEROSIS

多发性硬化症（MS）是一种进行性神经系统疾病，可能有自身免疫基础。 我们一直在测试克拉屈滨（2-CdA）作为MS治疗的安全性和有效性。目前的其他治疗方法都不令人满意，β干扰素和Copaxone对MS复发有部分影响。我们已经完成了慢性进展性MS的治疗试验，并表明克拉屈滨，一种免疫抑制剂，延缓疾病的进展两年或更长时间。 克拉屈滨治疗复发缓解型MS的双盲、安慰剂对照临床试验（子项目#288）刚刚完成。

Multiple sclerosis (MS) is a progressive neurologic disorder that is likely to have an autoimmune basis. We have been testing the safety and efficacy of cladribine (2-CdA) as a treatment for MS. Other current treatments are unsatisfactory, with Beta Interferon and Copaxone having a partial effect on relapses in MS. We have completed treatment trials in chronic progressive MS and have shown that cladribine, an immunosuppressive agent, retards the progression of the disease for two years or longer. A double-blind, placebo-controlled clinical trial of cladribine in relapsing-remitting MS (subproject #288) has just been completed.