How the Vaccinia virus protein C6, inhibits IFN-gamma signalling

布景主题：世界一流的基础生物科学牛痘病毒蛋白C6已被证明可以抑制IFN-γ的诱导，IFN-γ是免疫反应的关键细胞因子。该项目将有助于了解C6抑制这一途径的分子机制，既提高了我们对病毒/宿主相互作用和基本细胞生物学过程的理解。ENWW：-该项目有潜力利用高通量蛋白质组学/基因组学，但我可以应用生物信息学分析，以更好地了解病毒感染过程中基因表达/病毒宿主相互作用的变化。

Theme: World-Class Underpinning BioscienceThe Vaccinia virus protein C6 has been shown to inhibit the induction of IFN-gamma, a critical cytokine of the immune response. This project would sort to understand the molecular mechanism by which C6 can inhibit this pathway, both improving our understanding of virus/host interactions and fundamental cell biology processes. ENWW:- Project has the potential to utilise high throughput proteomics/genomics though which I can apply bioinformatics analysis to better understand the changes in gene expression/ virus host interactions during virus infection.