Investigating the Effect of Temperature on Pump-Driven Antibiotic Resistance towards Erythromycin in Escherichia coli

项目标题：研究环境温度对抗菌素耐药性进化的影响抗菌素是人类科学最伟大的发现之一，构成了现代医学的基石。然而，过去50年来对这些药物的灾难性投资不足导致了目前的情况，即所有已知抗生素都存在抗药性病原体，而没有新的抗生素类别出现。本项目将调查抗生素耐药性的一个关键方面，即环境温度对抗菌素耐药性演变的影响。为此，本项目将使用统计分析、数学建模和高分辨率成像来研究(I)温度、(Ii)外排泵的表达、以及(Iii)对常用抗生素的抗药性。因此，该项目将为解决目前的抗菌素耐药性危机提供新的数学和物理工具以及新知识。

Project title: Investigating the effect of the environmental temperature on the evolution of antimicrobial resistanceAntibiotics are one of the greatest discoveries of human science, and form the bedrock of modern medicine. However, a catastrophic lack of investment in these drugs over the past 50 years has led to the present scenario where drug resistant pathogens now exist for all known antibiotics, with no new classes of antibiotics on the horizon.This project will investigate a key aspect of antibiotic resistance, that is what is the impact of the temperature in the environment on the evolution of antimicrobial resistance.In order to so, this project will use statistical analysis, mathematical modelling and high-resolution imaging to investigate the correlation between (i) temperature, (ii) the expression of efflux pumps, and (iii) resistance to commonly used antibiotics.This project will therefore provide new mathematical and physical tools as well as new knowledge for tackling the current antimicrobial resistance crisis.