EVALUATION OF TREATMENTS OF DRUG DEPENDENCE IN HIV INFECTED PATIENTS

该项目评估减少药物滥用者艾滋病毒风险行为的方法，并评估药物和行为治疗对已感染艾滋病毒的阿片类药物依赖的安全性和有效性。一项随机临床试验研究了是否可以通过在基于凭证的应急管理中增加认知行为应对技能和复发预防干预来实现持续的艾滋病毒保护行为。 城市内美沙酮维持可卡因滥用者被教导：1）识别和寻找不携带艾滋病毒风险的强化来源; 2）发展适应性问题和情绪为重点的应对反应，以应对可能引发艾滋病毒风险行为的一般和药物特异性压力源。 数据正在分析中。

This project assesses methods for decreasing HIV-risk behaviors in substance abusers, and assesses the safety and efficacy of pharmacological and behavioral treatments for opioid dependence in those already infected with HIV. A randomized clinical trial examined whether sustained HIV-protective behaviors can be achieved by adding a cognitive-behavioral coping-skills and relapse-prevention intervention to voucher-based contingency management has been completed. Inner-city methadone-maintained cocaine abusers were taught: 1) to identify and seek out sources of reinforcement that do not carry risks of HIV; and 2) to develop adaptive problem-focused and emotion-focused coping responses to general and drug-specific stressors that might otherwise trigger HIV-risk behaviors. Data are being analyzed.