Animal Model of Ethanol-Induced Cardiomyopathy

描述(由申请人提供)：本建议书是为回应 国家酒精滥用和酒精中毒研究所征求建议 开发更接近人类疾病的新模型。关于中国石油天然气集团公司 乙醇对心肌收缩能力的影响已经持续了超过 过去的二十年里。对长期服用乙醇的动物的研究和 以前和现在研究的酒精引起的疾病模型都是 不能与人类的状况相比。可再生乙醇诱导 在动物身上很难产生心肌病。这阻碍了 这种疾病的实验研究。到目前为止还没有人产生充血 慢性酒精摄入动物模型中的心肌病或心力衰竭。

DESCRIPTION (provided by applicant): This proposal was prepared in response to the National Institute on Alcohol Abuse and Alcoholism request for proposals to develop new models that more closely mimic human disease. Studies on the effects of ethanol on myocardial contractility have been ongoing for over the last twenty years. Studies in animals chronically administered ethanol and models of ethanol-induced disease studied previously, as well as currently, do not compare well to the human condition. Reproducible ethanol-induced cardiomyopathy has been difficult to produce in animals. This has hindered experimental studies of this disease. No one to date has produced congestive cardiomyopathy or heart failure in an animal model of chronic ethanol intake.