GENERAL CLINICAL RESEARCH CENTER

这是一个竞争性的连续补助金提案， 西北大学临床研究中心和西北 纪念医院。GCRC自1961年以来一直得到资助， 在最近的补助金更新中，按每日津贴计算。 但由于 当前活动增加（今年住院天数超过750天） 并建议持续和增加活动（至1200名住院病人A 天），我们要求创建一个独立的，六个床位的GCRC。 哈利 N.贝蒂医学博士西北大学医学院院长， 作为一名私家侦探以及一个新的项目和助理项目骨干 董事，和成功的招聘为医学主席， 增加了神经病学、社区卫生和预防医学 以说明CRC当前和未来使用率的增加。 CRC的拨款更新有来自83个不同的48个提案 代表基础科学（细胞，分子， 结构生物学、药理学）和临床科学系 学校 临床部门已经扩大到包括医学， 儿科、神经科和泌尿科; 医学和两个在儿科是由校长代表 调查员和方案。 将要研究的科学的广度 在CRC中，由研究中心提交的方案证明 访问 这包括，按介绍顺序，对遗传学的研究， 家族性神经源性心脏病中加压素生理调节的研究 尿崩症由医学博士加里罗伯逊，项目主任;研究 AVP对肾脏钾、氢离子处理的影响 研究钾和氢的变化对 平衡AVP的肾功能，丹尼尔巴特列，医学博士。和威廉 Schleuter，医学博士;电生理昼夜节律性的研究 参数及其与自主神经系统张力的关系， Alan Kadish，医学博士;瘦型与肥胖型肾上腺髓质功能的研究 《男人和女人》作者：James Young，M.D.;肥胖机制的研究 在怀孕期间患有糖尿病的母亲的后代中， 对于那些母亲的瘦弱后代和那些母亲的肥胖后代来说， 非糖尿病妊娠，由Boyd Metzger，M.D.，和伯纳德·西尔弗曼 医学博士;对老年大脑保持记忆刺激能力的研究 作者：John Disterhoft，Ph.D.和医学博士布鲁斯诺顿;研究 罗伯特克雷格的艾滋病患者的胃肠道吸收不良， 医学博士;和1，25-二羟维生素D代谢的研究 患有低磷酸盐血症佝偻病的儿童及其正常兄弟姐妹 Langman，医学博士多萝西·邓洛普博士 拟提交的研究报告和 在更新申请中提出的其他人代表了 对人类疾病的病理生理学进行科学研究 跨越许多学科和人群，如果成功完成， 为未来的病人护理提供重要信息。

This is the competing continuation grant proposal for the General Clinical Research Center at Northwestern University and Northwestern Memorial Hospital. The GCRC has been continuously funded since 1961 and, in the most recent grant renewal, as per diem unit. However, because of current increased activity (over 750 inpatient A days this current year) and proposed sustained and increased activities (to 1200 inpatient A days), we are requesting the creation of a discrete, six bed GCRC. Harry N. Beaty, M.D., Dean of Northwestern University Medical School, continues as overall P.I., and a new cadre of Program and Associate Program Directors, and successful recruitments for the Chairs of Medicine, Neurology, and Community Health and Preventive Medicine, have been added to account for the current and future increased utilization of the CRC. This grant renewal for the CRC has 48 proposals from 83 different investigators, representing both Basic Science (Cell, Molecular, and Structural Biology, Pharmacology) and Clinical Science Departments of the School. The Clinical Departments have expanded to include Medicine, Pediatrics, Neurology, and Urology; five different divisions within medicine and two within Pediatrics are represented by principal investigator and protocol. The breadth of science that will be studied in the CRC is demonstrated by the protocols to be presented at the site visit. This includes, in order of presentation, studies on the genetics of the regulation of vasopressin physiology in familial neurogenic diabetes insipidus by Gary Robertson, M.D., Program Director; studies on the influence of AVP on the renal handling of potassium and hydrogen ion and studies of the influence of altered potassium and altered hydrogen balances on the renal functions of AVP by Daniel Batlle, M.D. and William Schleuter, M.D.; studies on the diurnal rhythmicity of electrophysiologic parameters and their relationship with autonomic nervous system tone, by Alan Kadish, M.D.; studies of adrenomedullary function in lean and obese men and women by James Young, M.D.,; studies of the mechanisms of obesity in the offspring of mothers who were diabetic during pregnancy compared to both the lean offspring of those mothers and obese offspring of nondiabetic pregnancies by Boyd Metzger, M.D., and Bernard Silverman, M.D.; studies of the ability of the aged brain to retain memory stimuli by John Disterhoft, Ph.D. and Bruce Naughton, M.D.; studies of gastrointestinal malabsorption in patients with AIDS by Robert Craig, M.D.; and studies on the metabolism of 1,25 dihydroxyvitamin D in children with hypophosphatemic rickets and their normal siblings by Craig Langman, M.D. and Dorothy Dunlop, PH.D. The studies to be presented and those others proposed in the renewal application represent state of the art scientific investigation into the pathophysiology of human diseases across many disciplines and populations and, if successfully completed, with yield important information for future patient care.