Effect zoledronic acid and risedronate on the preservation of the femoral head in a rat model of Perthes disease

珀尔特斯病（Legg-Perthes Disease）是一种常见的儿童疾病，它会导致生长中的髋关节塌陷和畸形。这可能导致成年后的关节炎，以及受影响一侧的腿短。原因尚不清楚。一种叫做双膦酸盐的药物已经被证明可以帮助患有成骨不全症（脆骨病）的儿童。我们相信，基于我们对这些药物对骨愈合的影响的广泛研究，它们也可以帮助患有珀尔塞斯病的儿童。虽然证明对成骨不全的儿童是安全有效的，但在让患有Perthes病的儿童面临任何副作用的风险之前，需要进行动物研究。有一种叫做自发性高血压大鼠的老鼠患上了和珀尔特斯病几乎一模一样的疾病。这项研究将对大量这样的大鼠进行治疗，并进行详细的研究，以确定它是否对保持髋关节的形状有积极的影响，以及研究这是如何发生的。一个成功的结果将为珀尔特斯病儿童的试验铺平道路，并可能导致避免手术和改善儿童的健康结果。

Perthes Disease (Legg-Perthes Disease) is a common childhood disorder, which leads to collapse and deformity of the growing hip joint. This can lead to arthritis in adult life, as well as a short leg on the affected side. The cause is as yet unknown. A class of drugs called bisphosphonates has been shown to help children with osteogenesis imperfecta (brittle bone disease). We believe, based on our extensive studies of the effect of these drugs on bone healing, that they could also help children with Perthes disease. Although proving to be safe and effective in children with osteogenesis imperfecta, before exposing children with Perthes disease to the risk of any side effects, animal studies are needed. A certain type of rat called the spontaneously hypertensive rat gets a condition almost exactly the same as Perthes disease. This study will treat a large number of these rats and perform detailed study into whether it has a positive effect on preserving the shape of the hip joint, as well as looking into how this actually occurs. A successful outcome would pave the way for trials in children with Perthes disease, and could result in the avoidance of surgery and improved health outcomes for the children.