Bruker Biospec 9.4T/40cm Bore MRI System

需要资金来购买9.4特斯拉场强/40厘米直径的核磁共振扫描仪，用于动物研究。作为主要用户的11名研究人员和作为次要用户的3名研究人员将共享该仪器，以加强他们由NIH/NSF资助的科学研究。该提案的目标是利用小动物模型的潜力，开发高场强成像技术，对大胆对比和神经元活动进行机制研究，特别是利用基因工程小鼠作为癌症研究的发现工具。介绍了每个主要用户的项目说明以及NCRR-SIG为每个项目带来的好处。这笔赠款的奖励将由威斯康星医学院(MCW)购买该仪器的资金补充。MCW还将为拟议的场地建设提供资金，支持运营费用和人员。随函附上学院院长的机构承诺书。NCRR-SIG将由MCW生物物理研究所(BRI)与学院的癌症中心和人类和分子遗传学中心联合管理。大口径将允许使用已经由BRI MR物理团队设计和建造的高性能梯度。这些主动屏蔽、高强度、高转换速率的梯度将允许使用部分Kspace梯度回声平面成像(GR-EPI)采集时间进程的图像。由BRI首创的部分k空间EPI允许空间分辨率翻一番，进一步促进了各种实验设计中空间和时间分辨率之间的权衡。可以对四维数据集--空间和时间--进行后处理，以便在时间和空间分辨率之间进行连续的权衡。购买该成像系统还将为威斯康星州提供资源，作为唯一可用的超高场和大口径动物仪器。

Funds are requested to enable the purchase of 9.4 Tesla field strength / 40 cm diameter bore MRI scanner for animal research. Eleven investigators as major users and three investigators as minor users will share this instrument to enhance their NIH/NSF funded scientific research. The goal of the proposal is to capitalize on the potential of small animal models in the development of high field imaging technology, mechanistic studies of BOLD contrast and neuronal activity, and particularly genetically engineered mice, as discovery tools in cancer research. The project description of each major user is presented along with the benefits of the NCRR-SIG for each project. The award from this grant will be supplemented with Medical College of Wisconsin (MCW) funds for purchase of the instrument. MCW will also provide funds for the proposed site construction, support of operating expenses and personnel. A letter of institutional commitment from the dean of the college is attached. The NCRR-SIG will be administered by the MCW Biophysics Research Institute (BRI) in alliance with the college's Cancer Center and the Human and Molecular Genetics Center. The large bore will permit use of high performance gradients already designed and built by the BRI MR physics team. These actively shielded, high-strength, high slew-rate gradients will permit acquisition of a time course of images using partial kspace Gradient Recalled Echo Planar Imaging (GR-EPI). Partial k-space EPI, pioneered by the BRI, permits doubling of the spatial resolution, further facilitating the trade-off between spatial and temporal resolution in a variety of experimental designs. Four-dimensional data sets - space and time - can be post-processed for a continuous tradeoff between temporal and spatial resolution. The purchase of this imaging system will also provide a resource for the state of Wisconsin as the only super-high field and large bore animal instrument available.