Effect of Testosterone Treatment Combined with Dietary Restriction on Body Fat Mass and Muscle Function in Obese Men: A Randomized Controlled Trial

肥胖是一种日益加重的健康和经济负担，它与男性睾丸素水平降低有关。虽然饮食限制和睾丸素治疗都能减少体内脂肪，但这两种方法的结合是否能实现更明显的脂肪减少尚不清楚。我们将对150名睾酮水平较低的肥胖男性进行为期12个月的严格的睾酮治疗临床试验。所有男性都将接受饮食干预，以诱导和保持体重减轻

Obesity, an increasing health and economic burden, is associated with lowered testosterone levels in men. While both dietary restriction and testosterone treatment reduce body fat, whether a combination of these two approaches achieves a more pronounced fat mass reduction is unknown. We will conduct a rigorous 12 month clinical trial of testosterone treatment in 150 obese men with a low testosterone level. All men will receive dietary intervention to induce and maintain weight loss