Muscle aging and gene expression balance in Caenorhabditis elegans

基于CRISPR-Cas9的基因组编辑现在在秀丽隐杆线虫中快速而直接，并在这个关键模型系统中开辟了全新的研究途径。对启动子区的原位精确操作将允许在体内对具有控制肌肉钙离子稳态作用的蛋白质的表达水平进行细微修饰。复杂钙离子通道调节系统亚基水平的不一致预计会导致肌肉老化，这是老年人活动能力下降的主要因素。更好地了解动物的肌肉老化可能会导致人类肌肉老化的延迟。

Genome editing based on CRISPR-Cas9 is now rapid and straightforward in Caenorhabditis elegans and has opened up entirely new avenues of research in this key model system. Precise manipulations of promoter regions in situ will allow subtle modification in vivo of expression levels of proteins with roles in control of muscle calcium ion homeostasis. Discordance in levels of subunits of the complex calcium ion channel regulatory system is predicted to lead to muscle ageing, the major factor in mobility decline in older people. A better understanding of muscle ageing in animals may lead to delaying of muscle ageing in people.