Lysophospholipid Modulation-Apoptosis-Murine Macrophages

描述(由申请人提供)：我建议检查抑制 溶血磷脂介质溶血磷脂酸(LPA)通过 刺激特定成员的GPCRs家族，称为内皮细胞 细胞分化基因(EDG)受体。EDG的真正细胞功能 受体尚未明确确定。然而，许多研究都有 证明了LPA能够引起各种生物反应。这个 这项研究的目标是确定参与的初始组件 溶血磷脂介导抑制细胞凋亡的机制。 最终，这项研究中获得的信息将使我们能够确定 溶血磷脂用来调节这种抑制的途径，以及 促进可以减轻这种影响的药物制剂的设计 抑制效应。

DESCRIPTION (provided by applicant): I propose to examine the inhibition of apoptosis by the lysophospholipid mediator, lysophosphatidic acid (LPA), via stimulation of specific members a family of GPCRs, known as the endothelial cell differentiation gene (EDG) receptors. The true cellular function of EDG receptors has yet to be clearly established. However, numerous studies have demonstrated the ability of LPA to elicit various biological responses. The goal of this study is to determine the initial components involved in the mechanism used by lysophospholipids to mediate the inhibition of apoptosis. Ultimately, the information obtained in this study will allow us to establish the pathway utilized by lysophospholipds to mediate this inhibition, and promote the design of pharmaceutical agents that could attenuate this inhibitory effect.