Modelling chronic toxicity in terrestrial mammals

小型哺乳动物(例如田鼠、林鼠)本身也为生态系统服务做出了贡献，也是猛禽等标志性捕食者的猎物。为了在维护生态系统服务的同时维护粮食安全，必须了解不同农药暴露模式在田间条件下如何导致生态毒理效应的机制。本项目的目的是开发毒物动力学-毒物动力学(TKTD)模型，以更好地了解、模拟和预测农药对野生动物的毒害效应，特别是对小型哺乳动物生长的影响。现有的对大鼠和小鼠的实验室毒性研究将用于开发和校准该模型。该模型旨在实现两个目标：A.体外到体内毒性外推对生长的影响；B.评估不同暴露模式在风险评估领域的影响。

Small mammals (e.g. field voles, wood mice) contribute to ecosystem services both in their own right and as prey for iconic predators such as birds of prey. In order to maintain food security while preserving ecosystem services it is important to understand the mechanisms of how different pesticide exposure patterns lead to ecotoxicological effects under field conditions. The aim of this project is to develop a toxicokinetic-toxicodynamic (TKTD) model to better understand, simulate and predict toxic effects of pesticides on wildlife, specifically effects on growth of small mammals. Existing laboratory toxicity studies with rats and mice will be used to develop and calibrate the model. The model aims to achieve two objectives: A. In-vitro to in-vivo toxicity extrapolation for effects on growth B. Assess the effects of different exposure patterns in the field for risk assessment.