LSD and Serotonin Receptor Function

描述(由申请人提供)： 精神分裂症是一种精神障碍，其核心症状包括 妄想，杂乱无章的思想和语言，以及幻觉。神经学 目前，幻觉形成的底物尚不清楚。在这 应用、生化和行为学实验将进行 检查致幻药物麦角酸的作用轨迹 二乙胺(LSD)。LSD被认为主要通过以下途径调节其行为 5-羟色胺-2A(5-HT2A)和5-HT2C(5-HT2C)受体。具体目标我会 探讨5-HT2A和5-HT2C受体在大鼠脑缺血再灌注损伤中的作用。 LSD大鼠脑内即刻早期基因c-fos的表达特定目标H 将利用直接显微输液分离出涉及到哪个脑部位(S LSD诱导的辨别性刺激。最后，我将检查具体的目标 术后5-HT2A和5-HT2C受体功能是否发生改变 反复接触LSD。一个长期的目标是了解神经机制。 一种有效的迷幻剂LSD的作用，以及这些神经元过程如何 在精神分裂症等疾病状态下出现功能障碍。

DESCRIPTION(Provided by applicant): Schizophrenia is a psychiatric disorder with core symptoms that include delusions, disorganized thought and speech, and hallucinations. The neural substrate for the formation of hallucinations is, at present, unclear. In this application, biochemical and behavioral experiments will be performed to examine the loci of action of the hallucinogenic drug lysergic acid diethylamide (LSD). LSD is thought to mediate its actions primarily through serotonin-2A (5-HT2a) and serotonin-2C (5-HT2c) receptors. Specific Aim I will examine the contribution of 5-HT2A and 5-HT2c receptors to the induction of the immediate early gene, c-fos, in rat brain after LSD treatment. Specific Aim H will utilize direct microinfusion to isolate which brain site(s) are involve in the LSD-induced discriminative stimulus. Finally, Specific Aim Ill will examine whether there are functional alterations of 5-HT2A and 5-HT2c receptors after repeated LSD exposure. A long-term goal is to understand the neuronal mechanism of action of LSD, a potent hallucinogen, and how these neuronal processes might be dysfunctional in a disease state such as schizophrenia.