STATISTICAL ASPECTS OF CVD CLINICAL TRIALS

本项目为期五年，旨在培养生物统计学家开展心血管疾病临床试验领域重要问题的生物统计研究，并为心血管疾病临床试验领域的其他研究工作者提供高水平的协同研究和咨询支持。培训针对的是博士前水平。学术课程将包括理论统计学和应用统计学的所有课程，这是健康科学统计学家博士学位课程的核心，以及临床试验方法学和心血管疾病的相关课程。研究和咨询方面的生物统计学培训将侧重于临床试验设计、纵向试验和交叉设计、序列分析、数据管理、生存分析、质量控制和测量问题、临床试验中的重采样方法、经验贝叶斯和贝叶斯方法等重要领域。典型的博士预科实习生将是大学毕业生，本科成绩优异，在数学方面的专业知识达到多变量微积分的水平。要求为五名博士预科学员提供五年的津贴和有关支助。生物统计系是公共卫生学院的一个组成部分，它拥有足够的人员和设施，可以在心血管疾病临床试验方面提供非常全面的培训方案。

DESCRIPTION (Applicant's Abstract) The proposed five-year program is designed to train biostatisticians to conduct biostatistical research relevant to important problems in the areas of cardiovascular disease clinical trials and to provide high-level collaborative research and consulting support to other research workers in the cardiovascular disease clinical trials field. The training is directed at the predoctoral level. The academic courses will include all those in theoretical and applied statistics, which are the core of a doctoral degree program for a statistician working in the health sciences, plus relevant courses in clinical trials methodology and cardiovascular diseases. Biostatistical training in research and consultation will focus on such important areas as the design of clinical trials, longitudinal trials, and cross-over designs, sequential analysis, data management, survival analysis, quality control and measurement issues, resampling methods in clinical trials, empirical Bayes and Bayes methodologies. The typical predoctoral trainee will be a college graduate with an excellent undergraduate record, expertise in mathematics to the level of multivariable calculus. Stipends and associated support are requested for five predoctoral trainees for five years. The Department of Biostatistics as a component of the School of Public Health, has available to it all the personnel and facilities sufficient to provide a very comprehensive training program in cardiovascular disease clinical trials.