PREDOCTORAL TRAINING: BIOORGANIC/BIOINORGANIC CHEMISTRY

这一修订后的建议寻求继续支持一个跨学科，博士前的培训计划集中在生物有机和生物无机化学。最初要求为12个毕业实习生职位提供支助，后来增加到15个。来自生物学、化学和化学工程系的13名教师将参加博士前学生的培训。该计划的目的是培养学生在化学设计，合成，阐明和有机和含金属的生物重要性分子的功能应用。通过强调跨学科研究，学生将接受培训，以应用化学观点，基于结构和机制的考虑，探索生物功能。通过化学合成和设计，学员将能够探索，修改和创造生物功能。在这次修订中，我们力求强调跨学科的培训，特别是鼓励我们的学生发展化学工具和原理可以有力地应用于生物系统的理解。设施将包括加州理工学院两个部门的研究和教学设施以及贝克曼研究所，化学家和生物学家在共享实验室资源中心进行研究。课程将为学生提供化学和生物学的基础，但重点将放在研究经验的背景下进行培训。该计划的潜在学生已经在加州理工学院估计超过70名学生，所有优秀的素质和人才，并与兴奋进行研究在化学和生物学的接口。我们提出了生物有机和生物有机化学的培训计划，利用化学设计来探索生物功能，成为加州理工学院的焦点，在那里学生在化学和生物学的界面上接受学术和工业研究的领导角色的培训。

This revised proposal seeks continued support for an interdisciplinary, predoctoral training program centered in bioorganic and bioinorganic chemistry. Support is requested initially for 12 graduate trainee positions, and increasing to 15. Thirteen faculty from the Divisions of Biology and Chemistry and Chemical Engineering will participate in training predoctoral students. The aim of the proposed program is the training of students in the chemical design, synthesis, elucidation, and functional application of organic and metal-containing molecules of biological importance. With this emphasis on interdisciplinary research, students will be trained to apply a chemical perspective, grounded in considerations of structure and mechanism, to explore biological function. Through chemical synthesis and design, trainees will become able to probe, modify, and create biological function. In this revision we seek to emphasize training across the disciplines, in particular to encourage our students to develop an understanding of where chemical tools and principles can be powerfully applied in biological systems. Facilities will include the research and teaching facilities of both Divisions at Caltech as well as the Beckman Institute, where chemists and biologists conduct research in shared laboratory resource centers. The course curriculum will provide students with a foundation in both chemistry and biology, but strong emphasis will be placed on training in the context of the research experience. The potential pool of students for the program already at Caltech is estimated as greater than 70 students, all of outstanding quality and talent, and with excitement for conducting research at the interface of chemistry and biology. We propose this training program in bioorganic and bioorganic chemistry, using chemical design to explore biological function, to become a focal point at Caltech, where students are trained for leadership roles in both academic and industrial research at the interface of chemistry and biology.