NEUROENDOCRINE INFLUENCES ON MAMMARY CANCER

说明：本修订后的延续申请提出了三个具体的 旨在解决褪黑激素在生长和生理中的作用， （1）确定受体途径，膜或 核，介导的生长抑制和ER调节作用， 褪黑激素;（2）开始描绘细胞通路激活 褪黑激素和视黄酸诱导MCF-7细胞凋亡;和（3） 将我们对褪黑激素和视黄酸的凋亡作用的研究 从体外环境到更生理相关的体内模型 系统 通过明确褪黑激素在乳腺肿瘤发生中的作用， 与其他激素途径的相互作用，这些研究将开始定义 决定应答性和不应答性的因素 在乳腺癌的诊断、治疗和预后中至关重要 癌症，并可能最终提供重要的见解，以预防 乳腺癌

DESCRIPTION: This revised continuation application proposes three specific aims designed to address the role of melatonin in the growth and physiology of human breast cancer: (1) to define the receptor pathway(s), membrane or nuclear, which mediate the growth-inhibitory and ER-modulatory effects of melatonin; (2) to begin to delineate the cellular pathways activated by melatonin and retinoic acid which induce apoptosis in MCF-7 cells; and (3) to move our studies of the apoptotic effects of melatonin and retinoic acid from the in vitro setting to a more physiologically relevant in vivo model system. By defining the role of melatonin in mammary tumorigenesis and its interaction with other hormone pathways, these studies will begin to define the determinants of hormone-responsiveness and hormone-unresponsiveness which are critical in the diagnosis, treatment, and prognosis of breast cancer and may ultimately provide important insight into the prevention of breast cancer.